三阴性乳腺癌组织中hsa_circ_0001785的表达与新辅助化疗疗效的相关性

Correlation between the expression of hsa_circ_0001785 in triple negative breast cancer and the efficacy of neoadjuvant chemotherapy

目的探讨三阴性乳腺癌(TNBC)组织中hsa_circ_0001785的表达与新辅助化疗(NAC)疗效的相关性。方法2021年10月~2023年2月收治的129例TNBC病人为研究组,同期本院行手术治疗的125例乳腺良性病变病人为对照组。TNBC病人NAC疗效的影响因素采用多因素logistic回归模型分析;采用受试者工作特征(ROC)曲线分析hsa_circ_0001785水平对TNBC病人NAC疗效的预测价值。结果与对照组(1.05±0.16)比较,研究组hsa_circ_0001785表达水平(2.47±0.39)升高,差异有统计学意义(P<0.05);与有效组(2.34±0.35)比较,无效组hsa_circ_0001785表达水平(3.48±0.56)升高,差异有统计学意义(P<0.05);hsa_circ_0001785在肿瘤直径>2 cm、发生淋巴结转移、组织分级较高的TNBC病人中呈高表达状态(P<0.05);hsa_circ_0001785高表达、肿瘤直径>2 cm、发生淋巴结转移和组织学分级高是影响TNBC病人NAC疗效的危险因素(P<0.05)。hsa_circ_0001785水平对TNBC病人NAC疗效具有一定预测价值。结论hsa_circ_0001785在TNBC组织中高表达,且hsa_circ_0001785水平对病人NAC疗效具有一定预测价值。

Objective To investigate the correlation between the expression of hsa_circ_0001785 in triple negative breast cancer(TNBC)and the efficacy of neoadjuvant chemotherapy(NAC).Methods A total of 129 patients with triple negative breast cancer who were admitted to our hospital from October 2021 to February 2023 were regarded as the study group,and 125 patients with benign breast lesions who underwent surgery in our hospital were served as the control group.The influencing factors of NAC efficacy in TNBC patients were analyzed by multivariate logistic regression model;receiver operating characteristic(ROC)curve was applied to analyze the predictive value of hsa_circ_0001785 level for NAC efficacy in triple negative breast cancer patients.Results Compared with the control group(1.05±0.16),the expression level of hsa_circ_0001785 in the study group(2.47±0.39)increased(P<0.05);compared with the effective group(2.34±0.35),the expression level of hsa_circ_0001785 in the ineffective group(3.48±0.56)increased(P<0.05);hsa_circ_0001785 was highly expressed in triple negative breast cancer patients with tumor diameter>2 cm,lymph node metastasis and high tissue grade(P<0.05);high expression of hsa_circ_0001785,tumor diameter>2 cm,occurrence of lymph node metastasis and high histological grade were risk factors for NAC efficacy in triple negative breast cancer patients(P<0.05).Hsa_circ_0001785 level has certain predictive value for NAC efficacy in TNBC patients.Conclusion Hsa_circ_0001785 is highly expressed in triple negative breast cancer,and the level of hsa_circ_0001785 has a certain predictive value for the efficacy of NAC in patients.