腹膜粘连的分子机制研究进展

Research progress on the molecular mechanism of peritoneal adhesions

腹膜粘连是术后最常见的并发症之一。腹膜粘连的形成是一个多因素、多阶段的复杂过程,多种炎症细胞及其分泌的细胞因子促使炎症反应慢性化、凝血级联反应的启动和纤维蛋白过度沉积,最终导致病理性腹膜粘连带形成。近年来的研究还突出了非编码RNA在腹膜粘连中的重要作用。

Peritoneal adhesions are one of the most common postoperative complications.The formation of peritoneal adhesions is a complex process with multiple factors and stages.Various inflammatory cells and their secreted cytokines promote the chronicity of inflammatory response,the initiation of coagulation cascade reaction and excessive deposition of fibrin,ultimately leading to the formation of pathological peritoneal adhesions.Research in recent years has also highlighted the important role of non-coding RNA in peritoneal adhesions.