加味参蓍补脾汤对肺脾气虚证反复呼吸道感染患儿疗效及免疫功能的影响

Effect of Supplemented Shenshi Bupi Decoction on the Efficacy and Immune Function of Children with Recurrent Respiratory Tract Infection of Lung Qi Deficiency Syndrome

目的观察加味参蓍补脾汤对肺脾气虚证反复呼吸道感染(RRTI)患儿疗效及免疫功能的影响。方法选取2023年8月-2024年2月苏州市吴江区儿童医院收治的RRTI患儿82例,根据治疗方法分为对照组(n=41)和观察组(n=41)。对照组服用脾氨肽口服冻干粉治疗;观察组在对照组基础上加用加味参蓍补脾汤治疗。连续治疗2月。比较两组患儿中医证候积分、临床疗效、体液免疫功能差异及不良反应。结果治疗后观察组患儿总有效率明显高于对照组(χ2=6.011,P<0.05)。治疗后观察组中医证候积分明显小于对照组(P<0.05);治疗后观察组体液免疫指标中免疫球蛋白A(IgA)、免疫球蛋白G(IgG)和免疫球蛋白M(IgM)的浓度均明显高于对照组(P<0.05)。结论常规西药治疗加用加味参蓍补脾汤治疗RRTI患儿可提高临床疗效,增强患儿免疫功能,改变其免疫失衡的状态,降低不良反应发生率。

Objective To observe the therapeutic effect and immune function of supplemented Shenshi Bupi Decoction on children with recurrent respiratory tract infections(RRTI)of Lung Qi deficiency syndrome.Methods A total of 82 children with RRTI admitted to our hospital from August 2023 to February 2024 were selected and divided into control group(n=41)and observation group(n=41)according to treatment methods.The control group was treated with lyophilized oral splenic peptide and the observation group was treated with supplemented Shenshi Bupi Decoction on the basis of control group.After 2 months of continuous treatment,the two groups were compared in terms of TCM evidence points,clinical efficacy,differences in humoral immune function and adverse reactions.Results After treatment,the total effective rate in the observation group was significantly higher than that in the control group(χ^(2)=6.011,P<0.05).The TCM syndrome score of the observation group was significantly lower than that of the control group(P<0.05).The concentrations of immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)in the observation group were significantly higher than those in the control group(P<0.05).Conclusion The integration of supplemented Shenshi Bupi Decoction with western medical treatment can improve the clinical efficacy,enhance the immune function of RRTI children,change their immune imbalance state,and reduce the incidence of adverse reactions.