白细胞介素1β基因-511C/T多态性与云南省彝族人群原发性高血压相关

Correlation between interleukin 1β-511C/T polymorphism and essential hypertension in the Yi ethnic group of Yunnan province

目的探讨白细胞介素1β基因-511C/T多态性与云南省彝族人群原发性高血压的相关性。方法用PCR-RFLP技术对云南省晋宁县双河乡85例彝族原发性高血压患者(EH组)和106例彝族健康人(对照组)的白细胞介素1β基因-511C/T基因多态性进行检测,通过SPSS 27.0软件分析基因型频率和等位基因频率,并进行关联性分析。结果EH组中白细胞介素1β基因的突变位点511的CC、CT、TT基因型频率分布分别为18.82%、44.71%、36.47%,对照组中分别为5.66%、26.42%、67.92%。2组的基因型频率相比较,差异具有统计学意义(P<0.05)。EH组C、T等位基因频率分别为41.18%、58.82%,对照组C、T等位基因频率为18.87%、81.13%。等位基因在2组间的频率差异具有统计学意义(P<0.05)。分别计算男性和女性的基因型频率与等位基因频率,2者都具有统计学差异(P<0.05)。结论白细胞介素1β基因-511C/T多态性分布与云南省彝族人群原发性高血压发病存在相关性,是云南彝族原发性高血压的遗传易感基因。

Objective To investigate the correlation between interleukin 1βgene-511C/T polymorphism of and essential hypertension in the Yi ethnic group of Yunnan province.Methods-511C/T polymorphism of interleukin 1βgene was detected by PCR-RFLP in 85 Yi patients with essential hypertension(EH group)and 106 Yi healthy people(control group)in Shuanghe Township,Jinning County,Yunnan Province.Genotype and allele frequencies were analyzed by SPSS 27.0 software,and association analysis was performed.Results The frequency distribution of CC,CT and TT genotypes at the mutation site 511 of the IL-1βgene in EH group was 18.82%,44.71%and 36.47%,respectively,and it was 5.66%,26.42%and 67.92%in the control group.The difference in genotype frequency between the two groups was statistically significant(P<0.05).The allele frequency of C and T in EH group was 41.18%and 58.82%,respectively,and the allele frequency of C and T in control group was 18.87%and 81.13%.The frequency difference of alleles between the two groups was statistically significant(P<0.05).Both genotype frequency and allele frequency found in males and females had statistical differences(P<0.05).Conclusions The distribution of IL-1βgene-511C/T polymorphism is related to the incident of essential hypertension among the Yi ethnic group Yunnan Province,and is the susceptibility gene of the Yi ethnic group to essential hypertension.