Piezo1在红细胞形态及功能调控中的作用

The role of Piezo1 in the regulation of erythrocyte morphology and function

Piezo1是一种机械敏感离子通道蛋白质,在哺乳动物细胞中广泛表达,能够感知机械力刺激并介导信号的转导。血液的主要细胞成分红细胞的细胞膜上也镶嵌有Piezo1。Piezo1通过介导Ca^(2+)流入细胞与Gardos通道(KCa3.1)形成串联,构成“Piezo1-Ca^(2+)-Gardos通道轴”来调节红细胞的形态及功能。但是当Piezo1表达异常或被特异性激动剂(Yoda1)过度激活后,也会导致红细胞形态异常及功能障碍,甚至引起相关遗传性疾病的发生。

Piezo1 is a mechanosensitive ion channel protein widely expressed in mammalian cells with the function of sensing mechanical stimuli and of mediating signaling,and is embedded in the membranes of erythrocytes,the major cellular component of blood.Piezo1 regulates the morphology and function of erythrocytes by mediating the influx of Ca^(2+)into the cell in crosstalk with the Gardos channel(KCa3.1),constituting the“Piezo1-Ca^(2+)-Gardos channel axis”.However,when Piezo1 is abnormally expressed or over-activated by its specific agonist(Yoda1),it can also lead to abnormal erythrocyte morphology and dysfunction,and even cause the development of related hereditary diseases.