小胶质细胞在阿尔茨海默病发病机制中的作用

The role of microglia in the pathogenesis of Azheimer′s disease

阿尔茨海默病(AD)是最常见的一种神经退行性疾病。小胶质细胞是中枢神经系统中固有的免疫细胞,调控和监测周围内环境的稳定。小胶质细胞被激活后作用有限,可吞噬部分淀粉样蛋白(Aβ),而Aβ增加后会引起过度激活的小胶质细胞诱发慢性神经炎性反应,进而产生神经毒性影响阿尔茨海默病的病程。即小胶质细胞在神经炎性反应中的作用及在AD发病过程中的作用不容忽视,探讨以小胶质细胞为潜在靶点,旨在为AD的发病机制和临床治疗提供新的切入点。

Alzheimer′s disease(AD)is the most common neurodegenerative disease.Microglia are inherent immune cells in the central nervous system,regulating and monitoring the stability of the surrounding environment.After activation,microglia have limited effects and can phagocytose part Aβ,However,AβIncreased levels of microglia can induce chronic neuroinflammatory responses,leading to neurotoxicity and affecting the course of Alzheimer′s disease.The role of microglia in neuroinflammatory response and the pathogenesis of Alzheimer′s disease can not be ignored.This study aims to explore the potential target of microglia and provide a new entry point for the pathogenesis and clinical treatment of Alzheimer′s disease.