中国儿童青少年龋齿患病率的Meta分析

Prevalence of caries among children and adolescents in China:a meta-analysis

目的 系统评价中国儿童青少年龋齿患病率,为儿童青少年龋齿预防和干预提供参考。方法 检索中国生物医学文献数据库、中国知网、万方数据知识服务平台、维普中文科技期刊数据库、PubMed和Web of Science数据库,收集2020年1月1日-2023年12月31日发表的关于中国3~18岁儿童青少年龋齿患病率的文献。采用R 4.4.0软件进行Meta分析;采用逐一剔除法进行敏感性分析;采用Begg秩相关检验和Egger检验评价发表偏倚。结果 检索相关文献561篇,最终纳入26篇。调查地点在中国东部地区14篇,中部地区4篇,西部地区8篇;样本量为95 594人,龋齿患病45 004例。Meta分析结果显示,儿童青少年龋齿患病率为48.11%(95%CI:41.58%~54.65%)。亚组分析结果显示,性别、地区、学段、城乡、地区经济水平不同的儿童青少年龋齿患病率差异无统计学意义(均P>0.05)。逐一剔除文献后,龋齿患病率为41.58%~54.65%,提示研究结果较为稳定。Begg秩相关检验和Egger检验提示无发表偏倚(均P>0.05)。结论 2020-2023年中国儿童青少年龋齿患病率为41.58%~54.65%。

Objective To systematically evaluate the prevalence of caries among children and adolescents in China,so as to provide the basis for the prevention and intervention of caries among children and adolescents.Methods Litera⁃ture on caries among children and adolescents aged 3 to 18 years was collected through SinoMed,CNKI,Wanfang Da⁃ta,VIP,PubMed and Web of Science published from January 1,2020 to December 31,2023.A meta-analysis was per⁃formed using R 4.4.0 software.Literature were excluded one by one for sensitivity analysis.Publication bias was as⁃sessed using Egger's test and Begg rank correlation test.Results Totally 561 publications were retrieved,and 26 eligi⁃ble literature were enrolled in the final analysis.The survey period spanned from 2020 to 2023.The survey sites for 14,4 and 8 eligible literature were eastern,central and western regions,respectively.A total of 95594 individuals were included,with 45004 cases of caries.Meta-analysis showed that the prevalence of caries among children and ado⁃lescents was 48.11%(95%CI:41.58%-54.65%).Subgroup analysis results showed that there were no statistically signifi⁃cant differences in the prevalence of dental caries across different genders,regions,educational stages,urban-rural ar⁃eas,and regional economic levels(all P>0.05).After sequentially excluding publications,the prevalence of caries ranged from 41.58%to 54.65%,indicating that the research results were relatively stable.Begg rank correlation test and Egg⁃er's test indicated no publication bias(all P>0.05).Conclusion The prevalence of caries among children and adoles⁃cents in China ranged from 41.58%to 54.65%from 2020 to 2023.