CD147在老年急性脑梗死患者血清中的表达及其与神经功能缺损及预后的相关性研究

Correlation between serum CD147 expression level and neurological impairment and prognosis in elderly patients with acute cerebral infarction

目的 探讨老年急性脑梗死患者血清中CD147表达水平与神经功能缺损及预后的关系。方法 选择2022年6月-2023年2月就诊于焦作煤业(集团)有限责任公司中央医院和新乡医学院第一附属医院的140例ACI患者(ACI组)和60名同期健康体检者(对照组)作为研究对象,检测并比较血清中CD147表达水平的差异。根据改良Rankin量表(mRS)将ACI患者分为预后良好组(n=92)和预后不良组(n=48)。ACI患者CD147表达水平与NIHSS评分的相关性采用Pearson法分析,采用Logistic回归分析ACI患者预后不良的危险因素,ACI患者预后不良的诊断学标志物采用ROC曲线分析。结果 对照组和ACI组中CD147表达水平分别为(45.34±3.27)μg/ml、(134.23±9.45)μg/ml,与对照组相比,ACI组中CD147表达水平显著升高(t=70.975,P<0.001)。ACI组中CD147表达水平与NIHSS评分具有显著正相关性,相关系数r=0.752,P=0.004。LDL-c(OR=1.896,P<0.001)、NIHSS评分(OR=2.005,P<0.001)、胱抑素C(OR=2.116,P<0.001)和CD147(OR=2.775,P<0.001)是ACI患者发生预后不良的独立危险因素。LDL-c、NIHSS评分、胱抑素C和CD147预测ACI患者发生预后不良的AUC分别为0.874、0.864、0.895和0.939,诊断敏感度和特异度均在80%以上。结论 ACI患者血清中CD147表达水平显著升高,CD147与ACI患者神经功能缺损严重程度有关,可作为ACI患者发生预后不良的一种血清学标志物。

Objective To investigate the relationship between the serum expression level of CD147 and neurological impairment and prognosis in elderly patients with acute cerebral infarction(ACI).Methods A total of 140 ACI patients(ACI group)who were admitted to the Central Hospital of Jiaozuo Coal Group and the First Affiliated Hospital to Xinxiang Medical University from June 2022 to February 2023,and 60 healthy individuals undergoing physical examinations during the same period(control group)were enrolled in this study.The difference in serum CD147 expression levels were detected and compared between the two groups.According to the modified Rankin Scale(mRS),all ACI patients were divided into good prognosis group(n=92)and poor prognosis group(n=48).The correlation between serum CD147 expression level and NIHSS score in ACI patients was analyzed by Pearson's method,the risk factors of poor prognosis in ACI patients were analyzed by Logistic regression.The diagnostic markers of the incidence of poor prognosis in ACI patients were analyzed by ROC curve.Results The serum expression levels of CD147 in the control and ACI groups were(45.34±3.27)mg/mL and(134.23±9.45)μg/mL,respectively.Compared with the control group,the serum expression level of CD147 in the ACI group was significantly increased(t=70.975,P<0.001).The serum CD147 expression level in the ACI group had a significant positive correlation with NIHSS score,with the correlation coefficient r=0.752,P=0.004.LDL-c(OR=1.896,P<0.001),NIHSS score(OR=2.005,P<0.001),Cystatin C(OR=2.116,P<0.001),and CD147(OR=2.775,P<0.001)were independent risk factors for poor prognosis in ACI patients.The AUC of LDL-c,NIHSS score,Cystatin C,and CD147 in predicting the incidence of poor prognosis in ACI patients were 0.874,0.864,0.895,and 0.939,respectively,and the diagnostic sensitivity and specificity were all more than 80%.Conclusions The expression level of CD147 in the serum of ACI patients is significantly increased,and CD147 is related to the severity of neurological deficits in ACI patients and can be used as a serological marker for poor prognosis in ACI patients.