个性化干预在重症急性胰腺炎患者CVVH治疗中的应用价值

Application value of individualized intervention in the treatment of severe acute pancreatitis by continuous veno-venous hemofiltration

目的 探讨个性化干预在重症急性胰腺炎患者连续性静脉血液滤过(CVVH)治疗中的应用。方法 选取2019年1月至2021年1月84例重症急性胰腺炎患者,依随机数表法均分2组,每组42例。对照组给予常规干预,观察组给予个性化干预,比较2组心理韧性与生活质量。结果 2组干预后心理弹性量表(CD-RISC)评分明显提高(P<0.05),观察组较对照组更高(P<0.05);干预后,观察组SRAHP评分高于对照组,差异有统计学意义(P<0.05)。干预前,2组患者内毒素、hs-CRP比较,差异无统计学意义(P>0.05);干预后,2组患者内毒素水平、hs-CRP显著低于干预前(P<0.05),且观察组患者的内毒素水平、hs-CRP显著低于对照组(P<0.05);干预后观察组健康状况调查量表(SF-36)评分高于对照组(P<0.05)。结论 重症急性胰腺炎患者CVVH治疗中给予个性化干预,能够改善患者治疗效果,提高患者心理韧性及生活质量。

Objective To investigate the application of individualized intervention in the treatment of severe acute pancreatitis by continuous veno-venous hemofiltration(CVVH).Methods A total of 84 patients with severe acute pancreatitis treated from January 2019 to January 2021 were randomly divided into 2 groups(42 cases/group)according to random number table method.The control group received routine intervention and the observation group received individualized intervention.The psychological toughness and quality of life of the two groups were compared.Results The Connor-Davidson Resilience Scale(CD-RISC)scores in both groups after intervention significantly increased(P<0.05),and significantly higher in the observation group than the control group(P<0.05).After the intervention,the Self Rated Abilities for Health Practices(SRAHP)score of the observation group was significantly higher than that of the control group(P<0.05).Before intervention,there were no significant differences in endotoxin,hypersensitive C-reactive protein(hs-CRP)between groups(P>0.05),which,after intervention,were significantly lower than those before intervention in both groups(P<0.05),and significantly lower in the observation group than the control group(P<0.05).After intervention,the score of 36-Item Short-Form Survey(SF-36)in the observation group was significantly higher than the control group(P<0.05).Conclusion Individualized intervention in CVVH treatment of severe acute pancreatitis can improve the therapeutic effect,psychological toughness and quality of life.