铁死亡调控机制在骨肉瘤中的研究进展

Research progress of regulation mechanism of ferroptosis in osteosarcoma

骨肉瘤(osteosarcoma, OS)是儿童和青少年最常见的原发性恶性骨肿瘤,其恶性程度高,预后极差,传统的辅助治疗方式因其耐药性等问题已达瓶颈期。铁死亡是近年来被发现的一种新的细胞死亡方式,其典型特征是铁依赖性的脂质过氧化物的过度积累。铁死亡已被证实与OS的发展进程具有密切关系,可以抑制OS的增殖和转移并显著诱导其死亡,改善骨肉瘤患者的预后,提高生存率。目前对于铁死亡与骨肉瘤之间的研究与综述多从单一方面,且论点与临床实际之间存在偏倚。本文总结了调控铁死亡的主要机制及其在OS治疗方面的进展,从临床角度出发将铁死亡与骨肉瘤之间的关系进行系统归类,将铁死亡在诱导骨肉瘤死亡、预防转移、降低耐药性方面分别进行论述,旨在为铁死亡治疗骨肉瘤提供新的思路和途径。

Osteosarcoma(OS)is the most common primary malignant bone tumor in children and adolescents,with high malignancy and poor prognosis.Traditional adjuvant therapy has encountered the bottleneck period due to its drug resistance and other problems.Ferroptosis is a new mode of cell death discovered in recent years,which is typically characterized by iron-dependent excessive accumulation of lipid peroxides.Ferroptosis has been confirmed closely related to the development of osteosarcoma(OS),which can inhibit the proliferation and metastasis of OS,induce cell death,and improve the survival and prognosis.At present,the relationship between ferroptosis and OS has mostly been studied from a single aspect,and there is a bias between the argument and clinical practice.This article summarized the main mechanisms of ferroptosis and its advancement in OS treatment,systematically categorized the relationship between ferroptosis and OS from a clinical perspective,and deliberated on ferroptosis in terms of inducing cell death,preventing metastasis,and reducing drug resistance of OS.Our study aimed to provide new concepts and approaches for the treatment of OS through ferroptosis.