藏红花提取物鼻喷剂治疗中-重度持续性变应性鼻炎的临床疗效观察

Clinical observation on the efficacy of saffron extract nasal spray in the treatment of moderate to severe persistent allergic rhinitis

目的观察藏红花提取物鼻喷剂治疗中-重度持续性变应性鼻炎(AR)的临床效果。方法90例中-重度持续性AR患者随机分为治疗组(45例)和对照组(45例)。对照组予丙酸氟替卡松鼻喷雾剂喷鼻,氯雷他定片和孟鲁司特片口服;治疗组加用藏红花提取物鼻喷剂喷鼻,其他治疗同对照组;疗程均为4周。分别采集两组患者治疗前、治疗2周后、治疗4周后的鼻-结膜炎相关生活质量问卷(RQLQ)分值、鼻部症状总分值(TNSS)、鼻内镜检查分值进行分析比较,然后比较二组的总有效率。结果治疗2周及4周后,两组患者RQLQ评分和鼻内镜检查评分均有显著改善,但藏红花提取物鼻喷剂治疗组改善明显优于对照组(P<0.05)。治疗2周及4周后,两组患者的TNSS评分均有显著改善,但藏红花提取物鼻喷剂治疗组与对照组的疗效差异仅在治疗4周后显示有统计学意义(<0.05)。治疗4周后,藏红花提取物鼻喷剂治疗组总有效率95.0%,对照组为84.2%,差异有统计学意义(<0.05)。结论藏红花提取物鼻喷剂联合AR一线治疗用药,能够更有效地改善AR患者症状和体征,提高生活质量。

Objective To observe the clinical efficacy of saffron extract nasal spray(SENS)in the treatment of moderate to severe persistent allergic rhinitis(AR).Method Ninety patients with moderate to severe persistent AR were randomly divided into treating group(TG)and control group(CG),with 45 cases in each.The cases in CG were given the therapy composed of the first-line drugs recommended by AR guidelines,i.e.fluticasone propionate nasal spray(FPNS)plus loratadine and montelukast tablets orally taken,while those in TG were given SENS combined with the therapy as used among the cases in CG,with a therapeutic course lasted for 4 weeks for both groups.Then,collected and analyzed were such data as naso-conjunctivitis related Quality of Life questionnaire(RQLQ),the scores of nasal symptom total score(TNSS),and nasal endoscopy score,done at these time points of before treatment,by the end of the 2nd week and the 4th week following the treating respectively.At last,followed was the total effective rates evaluation in a comparative way between the two groups.Result By the end of the 2nd week and the 4th week following the treating,RQLQ scores and nasal endoscopy scores were all significantly improved in both groups,when compared with that seen before treatment,but the improvement was obviously higher in TG than in CG(P<0.05).Also,by the end of the 2nd week and the 4th week following the treating,TNSS scores of the two groups were significantly improved as well,when compared with that before treatment,but the improvement with statistical significance was only seen at the time point by the end of the 4th week following the treating,with that markedly higher in TG than in CG(P<0.05).As a result of comparative analysis between the two groups,the total effective rate of TG was 95.0%,significantly higher than the rate of 84.2%in CG(P<0.05).Conclusion The therapy combined saffron extract nasal spray with the first-line treatment strategy,as recommended by AR guidelines,can improve AR related symptoms and signs to elevate the quality of life for cases with AR much significantly.