基于WOS核心数据库进行CiteSpace全球人源骨髓间充质干细胞研究热点及可视化分析

Based on WOS Core Database,CiteSpace Global Research Hotspot and Visual Analysis of Human Bone Marrow Mesenchymal Stem Cells

目的 在WOS核心数据库通过CiteSpace对近三十年全球人源骨髓间充质干细胞(hBMMSC)研究现状和趋势进行量化分析。方法 通过WOS核心数据库检索1995-2023年间全球发表的hBMMSC相关文章,利用CiteSpace软件对发文量、国家、机构、学科、作者、关键词等数据进行文献计量学分析。结果 本研究共纳入4 280篇文章,美国1 194篇发文最多,哈佛大学95篇是发文最多机构,Chen Guoping和Tuan Rocky S分别发文25篇是发文最多的作者,高频关键词经聚类后最多的是组织工程。结论 过去近三十年,hBMMSC相关研究持续增长,研究重点从早期的基础研究包括分子机制、病生特点、发育生物学等方向向临床应用研究转化,侧重组织工程研发、hBMMSC微泡研究、hBMMSC与癌症关系等方向,本研究可以为hBMMSC深入研究提供指导。

Objective The research status and trends of human bone marrow mesenchymal stem cells (hBMMSC) in the past 30 years were quantitatively analyzed by CiteSpace in WOS core database. Methods WOS core database was used to search hBMMSC related articles published worldwide from 1995 to 2023, and CiteSpace software was used to conduct bibliometric analysis on the number of publications, countries, institutions, disciplines, authors, keywords and other data. Results A total of 4 280 articles were included in this study, of which 1 194 were published in the United States, 95 were published by Harvard University, 25 were published by Chen Guoping and Tuan Rocky S respectively, and 1 024 were published by cell biology. The most high-frequency keywords are tissue engineering after clustering. Conclusion In the past nearly 30 years, hBMMSC related research has continued to increase, and the research focus has been transformed from early basic research including molecular mechanism, pathogenic characteristics, and developmental biology to clinical application research, focusing on tissue engineering research and development, hBMMSC microvesicle research, and the relationship between hBMMSC and cancer, etc. This study can provide guidance for in-depth research on hBMMSC.