神曲消食口服液治疗小儿轮状病毒感染性腹泻的疗效观察

Observation of curative effect of Shenqu Xiaoshi oral liquid on rotavirus infectious diarrhea in children

目的探讨神曲消食口服液联合喜炎平治疗小儿轮状病毒感染性腹泻的疗效及对免疫功能的影响。方法将200例轮状病毒感染性腹泻患儿按照治疗方法均分为2组,对照组患儿予以喜炎平治疗,试验组患儿予以神曲消食口服液联合喜炎平治疗,比较2组治疗效果及对患儿炎性因子及免疫功能的影响。结果试验组临床总有效率高于对照组(P<0.05);治疗后,试验组患儿中医证候积分、血清白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α、干扰素(INF)-γ、超敏C-反应蛋白(hs-CRP)水平及CD8^(+)水平均低于对照组(P<0.05),血清CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)水平均高于对照组(P<0.05)。试验组患儿止泻时间早于对照组,轮状病毒转阴率高于对照组(P<0.05)。结论神曲消食口服液联合喜炎平治疗小儿轮状病毒感染性腹泻能快速缓解患儿症状,减轻炎症反应,提高免疫功能。

Objective To explore the therapeutic effect of Shenqu Xiaoshi oral liquid combined with Xiyanping on children with rotavirus infected diarrhea and its impact on immune function.Methods A total of 200 children with rotavirus infected diarrhea were diveded into two groups according to treatment methods.The control group was treated with Xiyanping.The experimental group was treated with Shenqu Xiaoshi oral liquid combined with Xiyanping.The therapeutic effects and impacts on inflammatory factors and immune function were compared between the two groups.Results The total effective rate of clinical efficacy was higher in the experimental group than that in the control group(P<0.05).After treatment,traditional Chinese medicine(TCM)syndrome scores,serum levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),interferon-γ(INF-γ),hypersensitive C-reactive protein(hs-CRP)and CD8^(+)were lower in the experimental group than those in the control group(P<0.05),the serum levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)were higher than those of the control group(P<0.05).The antidiarrheal time was earlier in the experimental group than that of the control group(P<0.05),and the negative rate of stool rotavirus was higher than that of the control group(P<0.05).Conclusion The combination of Shenqu Xiaoshi oral liquid and Xiyanping in the treatment of children with rotavirus infected diarrhea can quickly relieve symptoms of children,reduce inflammatory reactions and improve immune function.