脓毒症性凝血病诊疗中国专家共识(2024版)

Chinese expert consensus on the diagnosis and treatment of sepsis-induced coagulopathy(2024 edition)

脓毒症性凝血病(SIC)是脓毒症导致的血管内皮损伤和凝血紊乱,是导致脓毒症患者死亡的重要因素。对SIC实现早期诊断和治疗有望改善患者的预后。2019年国际血栓止血学会(ISTH)颁布了首部SIC诊疗指南,但我国尚无相关规范。因此,中国医药教育协会血栓与止血危重病专业委员会和全军重症医学专业委员会共同编写了《脓毒症性凝血病诊疗中国专家共识(2024版)》。该共识包括发病机制、分型、实验室评估、诊断和治疗等5个部分,共14条推荐意见,以便指导相应的临床工作。

Sepsis-induced coagulopathy(SIC),a critical and potentially lethal condition arising from sepsis,results in endothelial damage and significant coagulation dysregulation,making it a major factor contributing to mortality among sepsis patients.Early diagnosis and treatment of SIC are expected to improve the prognosis of sepsis patients.In 2019,the International Society on Thrombosis and Hemostasis(ISTH)issued the first guidelines for the diagnosis and treatment of SIC,but there are no corresponding protocols in China.Therefore,Chinese Society of Thrombosis,Hemostasis and Critical Care,Chinese Medicine Education Association,and Chinese People's Liberation Army Professional Committee of Critical Care Medicine jointly formulated the "Chinese Expert Consensus on the Diagnosis and Treatment of Sepsis-induced Coagulopathy (2024 edition). " This consensusincludes 5 parts: pathogenesis, classification, laboratory approaches, diagnosis and treatment, with a total of 14 evidence-basedrecommendations to guide clinical practice.