摘要
Non-obstructive azoospermia(NOA),the lack of sperm in the ejaculate due to failure of spermatogenesis,can result from a variety of diverse factors,with genetic factors accounting for~30%of NOA cases,including chromosomal aberrations,Y-chromosome microdeletions,and monogenic variants(Tang et al.,2022).More than 2000genes are known to participate in spermatogenesis,and>400 genes specifically linked to azoospermia have been identified through studies in mouse models(Krausz and Riera-Escamilla,2018).However,relatively few genes associated with azoospermia in mice have been verified in humans.
基金
supported by the National Key R&D Program of China(2023YFC2705503)
Major Innovation Projects in Shandong Province(2021ZDSYS16)
the National Natural Science Foundation of China(82071699 and 82371619)
CAMS Innovation Fund for Medical Sciences(2021-I2M-5-001)
the Basic Science Center Program of NSFC(31988101)
Science Foundation for Distinguished Young Scholars of Shandong(ZR2021JQ27)
Taishan Scholars Program for Young Experts of Shandong Province(tsqn202103192)。
