摘要
Pericytes,the mural cells enveloping small vessels,play a crucial role in maintaining the integrity of the blood-brain barrier(BBB)(Armulik et al.,2010;Daneman et al.,2010).Their loss leads to significant defects in BBB function,characterized by increased transcytosis across endothelial cells(ECs),diminished deposition of the cerebrovascular basement membrane,and compromised differentiation of astrocyte end-feet(Armulik et al.,2010;Daneman et al.,2010).
基金
supported by the National Key R&D Program of China(2019YFA0801603 to J.L.)
National Natural Science Foundation of China(31701265 to X.P.)
Shanghai Natural Science Foundation(22ZR1469700 to J.L.)
SA-SIBS Scholarship Program(to J.L.)
Youth Innovation Promotion Association of Chinese Academy of Sciences(to J.L.)。
