摘要
Circular RNAs(circRNAs)are a class of endogenous,singlestranded,covalently closed,mostly non-coding RNAs that are produced by back-splicing that links a downstream splice-donor site with an upstream splice-acceptor site(Chen,2016;Kristensen et al.,2019).CircRNAs have been reported to have important regulatory functions,such as acting as miRNA(Hansen et al.,2013;Memczak et al.,2013)or protein(Ashwal-Fluss et al.,2014)sponge to regulate gene expression,acting as scaffolds to mediate the formation of complexes(Du et al.,2016),and being translated into small functional peptides(Pamudurti et al.,2017).Notwithstanding,of millions of known circRNAs,those with demonstrated functions are a tiny fraction.
基金
supported by the National Natural Science Foundation of China(32270704,32100518 and 32472630)
National Science and Technology Innovation 2030(2022ZD0214400)
Engineering Shanghai Jiao Tong University(YG2022QN084)
the U.S.National Institutes of Health(R35GM139484 to J.Z.)。
