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细胞衰老与妊娠

Cellular senescence and pregnancy
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摘要 细胞衰老是一种应激诱导的终末细胞周期停滞程序。衰老在许多生理和病理条件下的影响已经很明显。研究表明,细胞衰老在健康妊娠的发展和进展中起着决定性的作用。母胎组织(蜕膜和胎盘)的过早衰老与许多不良妊娠结局有关,包括复发性流产、复发性植入失败、胎儿生长受限和子痫前期。本文结合最新相关文献,综述细胞衰老及其与正常妊娠进展和不良妊娠结局的关系。 Cellular senescence involves a stress-induced program that leads to terminal cell cycle arrest.The effects of senescence are evident in many physiological and pathological conditions.Studies have shown that cellular senescence plays a decisive role in the development and progression of a healthy pregnancy.Premature senescence of maternal and fetal tissues(decidua and placenta)is as-sociated with many adverse pregnancy outcomes,including recurrent miscarriages,recurrent implantation failures,fetal growth restric-tion,and pre-eclampsia.This article provides a thorough review of cellular senescence and its relation to normal pregnancy progression and adverse pregnancy outcomes through a comprehensive analysis of the latest literature on the topic.
作者 任佳杰 胡蝶 刘佳宁 郭鲁秦 冯晓玲 Ren Jiajie;Hu Die;Liu Jianing;Guo Luqin;Feng Xiaoling(Graduate School,Heilongjiang University of Chinese Medicine;Department Two of Gynecology,First Affiliated Hospital of Heilongjiang University of Chinese Medicine)
出处 《重庆医科大学学报》 CAS CSCD 北大核心 2024年第11期1361-1366,共6页 Journal of Chongqing Medical University
基金 国家自然科学基金面上资助项目(编号:82174421) 黑龙江省自然科学基金资助项目(编号:ZD2021H006) 黑龙江省重点研发计划资助项目(编号:2022ZX60C19) 黑龙江中医药大学研究生创新科研资助项目(编号:2022yjscx003)。
关键词 细胞衰老 子宫内膜基质细胞 滋养细胞 胎盘 妊娠 cellular senescence endometrial stromal cell trophoblast placenta pregnancy
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