白癜风ICC轴发病机制及JAK抑制剂研究进展

Research progress on the pathogenesis of ICC axis and JAK inhibitors in vitiligo

白癜风是一种常见的获得性色素脱失性疾病,其特征在于黑素细胞的破坏而产生白色斑块。目前白癜风无一致、长期和持久的治疗方法。JAK抑制剂被认为是治疗白癜风有潜力的方法之一,其通过抑制JAK-信号转导与转录激活因子信号通路,调节免疫反应,促进黑素细胞再生与迁移,从而改善白癜风患者的皮损状况。临床试验证实,JAK抑制剂治疗白癜风的有效性及安全性,然而,其长期疗效及潜在不良反应仍需进一步研究和探讨。JAK抑制剂为白癜风的治疗提供新的方法和方向。本文综述JAK抑制剂在白癜风治疗中的研究进展,包括其作用机制、临床应用及疗效评价等多方面,供临床参考。

Vitiligo is a prevalent acquired depigmentation disorder characterized by the destruction of melanocytes,resulting in the manifestation of white patches.At present,there is no consistent,long-term and long-lasting treatment method for vitiligo.JAK inhibitors are considered one of potential methods in the treatment of vitiligo,which regulate immune responses,promote melanocyte regeneration and migration,improve the condition of vitiligo patients’skin lesions by inhibiting JAK-signal transducer and activator of transcription signaling pathway.Clinical trials have confirmed the effec-tiveness and safety of JAK inhibitors in treating vitiligo.However,their long-term efficacy and potential adverse reactions still need further research and exploration.JAK inhibitors provide new methods and directions for the treatment of vitiligo.This article reviews research progress of JAK inhibitors in the treatment of vitiligo,including mechanisms of action,clinical application and efficacy evaluation,for clinical reference.