脊髓损伤后细胞自噬与炎症反应的相关信号通路研究进展

Research progress on signaling pathways related to cellular autophagy and inflammatory response after spinal cord injury

脊髓损伤(SCI)是由各种因素导致脊髓结构和功能破坏的严重致残性病变。SCI可激活多种炎症细胞及相关信号通路,在损伤部位形成复杂的炎症微环境,影响SCI修复。细胞自噬是真核细胞中维持细胞稳态的重要调节机制,通过调控自噬可维持炎症反应的平衡,炎症也可反作用于自噬,在SCI的病理生理过程中发挥重要作用。近年来,自噬和炎症在疾病中的机制备受关注,理清“SCI-信号通路-细胞自噬和炎症”的链条关系有利于把握SCI后动态病理变化,并找到改善SCI的方法。本文综述国内外关于SCI后细胞自噬和炎症反应的相关信号通路,以此为靶点为SCI的治疗提供新思路。

Spinal cord injury(SCI)is a severe disabling lesion caused by various factors that damage structure and function of spinal cord.Various inflammatory cells and related signaling pathways are activated after SCI,forming a complex inflammatory microenvironment at the site of injury,which affects repair of SCI.Cellular autophagy is an important regulatory mechanism for maintaining cellular homeostasis in eukaryotic cells.By regulating autophagy,the balance of inflammatory response can be maintained,and inflammation can also counteract autophagy,playing an important role in pathological and physiological processes of SCI.In recent years,the mechanisms of autophagy and inflammation in diseases have received much attention.Clarifying chain relationship between“SCI-signaling pathway-cellular autophagy and inflammation”is beneficial to grasp dynamic pathological changes after SCI and find ways to improve SCI.This article reviews relevant signaling pathways of cell autophagy and inflammatory response after SCI both domestically and internationally,and using them as targets may provide new ideas for treatment of SCI.