妇科肿瘤静脉血栓栓塞预防中抗凝药物使用情况分析

Analysis of the use of anticoagulant drug in the prevention of venous thromboembolism in gynecological tumors

目的分析妇科肿瘤静脉血栓栓塞症(VTE)预防中的抗凝药物使用现况以及合理性。方法回顾性选取2022年1月至2024年1月在亳州市人民医院进行VTE预防抗凝药物使用的100例妇科肿瘤患者的病历资料开展调查分析。观察VTE预防中的不同类型抗凝药物使用情况,对比不同年龄段、不同治疗方式以及不同Caprini评分患者的VTE预防抗凝药物使用率及不合理用药类型及占比情况。结果抗凝药物使用种类以依诺肝素钠注射液为主要类型(60.00%),其次为低分子量肝素钠注射液(17.00%)、低分子量肝素钙注射液(16.00%)以及屈肝素钙注射液(7.00%)。41~60岁患者使用抗凝药物率(73.00%)高于≤40岁(4.00%)、61~73岁患者(23.00%),差异有统计学意义(P<0.05)。手术治疗患者使用抗凝药物率(65.00%)高于放疗治疗(7.00%)、化疗(10.00%)、放疗+化疗(30.0%)、其他治疗(15.00%),差异有统计学意义(P<0.05)。高危患者的VTE预防抗凝药使用率(59.00)高于低危患者(41.00),差异有统计学意义(P<0.05)。用药合理性评估发现不合理用药占26.00%(26/100),其中用药疗程不合理为主要类型,占比12.00%(12/100)。结论妇科肿瘤患者中VTE预防有关抗凝药物的使用占据一定比例,同时存在不合理用药现象,需采取相应措施,以确保用药的有效性、合理性以及安全性,减少妇科肿瘤患者的VTE发生。

Objective To analyze the use of anticoagulants drug in the prevention of venous thromboembolism(VTE)in gynecological tumors.Methods A total of 100 gynecological tumor patients who received VTE preventive anticoagulant drugs in Bozhou People's Hospital were retrospectively from January 2022 to January 2024 investigated and analyzed,and the use of different types of anticoagulant drugs in VTE prevention was observed.The utilization rate of VTE preventive anticoagulant drugs,irrational drug use types and proportion of patients with different age groups,different treatment methods and different Caprini scores were compared.Results The type of anticoagulants used was dominated by enoxaparin sodium injection(60.00%),followed by low molecular weight heparin sodium injection(17.00%),low molecular weight heparin calcium injection(16.00%),and drotrecogin calcium injection(7.00%).The use rate of anticoagulant drugs in patients aged 41 to 60 years(73.00%)was higher than that in patients aged≤40 years(4.00%)and 61 to 73 years(23.00%),and the difference was statistically significant(P<0.05).The rate of using anticoagulant drugs in surgical treatment(65.00%)was higher than that in radiotherapy(7.00%),chemotherapy(10.00%),radiotherapy+chemotherapy(30.0%)and other treatment(15.00%),and the difference was statistically significant(P<0.05).The utilization rate of VTE prophylactic anticoagulant in high-risk patients(59.00%)was higher than that in low-risk patients(41.00%),and the difference was statistically significant(P<0.05).Rational evaluation of drug use found that irrational drug use accounted for 26.00%(26/100),and irrational drug duration was the main type,accounting for 12.00%(12/100).Conclusion The use of anticoagulant drugs for VTE prevention occupies a certain proportion in gynecological tumor patients,and irrational drug use exists.Corresponding measures should be taken to ensure the effectiveness,rationality and safety of drug use and reduce the occurrence of VTE in gynecological tumor patients.