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马来酸麦角新碱治疗宫缩乏力性产后出血患者的效果

Effects of Ergometrine maleate in treatment of patients with postpartum hemorrhage due to uterine inertia
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摘要 目的:观察马来酸麦角新碱治疗宫缩乏力性产后出血患者的效果。方法:回顾性分析2021—2023年该院收治的68例宫缩乏力性产后出血患者的临床资料,根据治疗方法不同将其分为对照组和观察组各34例。对照组采用米索前列醇治疗,观察组在对照组基础上采用马来酸麦角新碱治疗,比较两组临床疗效、治疗前后氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)]水平、治疗后72 h不良反应发生率和子宫复旧不良发生率。结果:观察组治疗总有效率为100.00%(34/34),高于对照组的82.35%(28/34),差异有统计学意义(P<0.05);治疗后,两组MDA水平均低于治疗前,且研究组低于对照组,两组SOD水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);观察组子宫复旧不良发生率为2.94%(1/34),低于对照组的23.53%(8/34),差异有统计学意义(P<0.05)。结论:在米索前列醇治疗基础上采用马来酸麦角新碱治疗宫缩乏力性产后出血患者可提高治疗总有效率,改善氧化应激指标水平,降低子宫复旧不良发生率,效果优于单纯米索前列醇治疗。 Objective:To observe effects of Ergometrine maleate in treatment of patients with postpartum hemorrhage due to uterine inertia.Methods:The clinical data of 68 patients with postpartum hemorrhage due to uterine inertia admitted to this hospital from 2021 to 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,34 cases in each group.The control group was treated with Misoprostol,while the observation group was treated with Ergometrine maleate on the basis of that of the control group.The clinical efficacy,the levels of oxidative stress indexes[superoxide dismutase(SOD)and malondialdehyde(MDA)]before and after the treatment,the incidence of adverse reactions 72 h after the treatment,and the incidence of poor uterine involution were compared between the two groups.Results:The total effective rate of the observation group was 100.00%(34/34),which was higher than 82.35%(28/34)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the MDA levels of the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;the SOD levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The incidence of poor uterine involution in the observation group was 2.94%(1/34),which was lower than 23.53%(8/34)in the control group,and the difference was statistically significant(P<0.05).Conclusions:On the basis of Misoprostol treatment,Ergometrine maleate can improve the total effective rate of treatment,improve the levels of oxidative stress indexes and reduce the incidence of uterine involution in the patients with postpartum hemorrhage due to uterine inertia.Moreover,it is superior to simple Misoprostol treatment.
作者 赵真真 ZHAO Zhenzhen(Department of Obstetrics and Gynecology of Pingdingshan the Second People’s Hospital,Pingdingshan 467000 Henan,China)
出处 《中国民康医学》 2024年第23期50-52,共3页 Medical Journal of Chinese People’s Health
关键词 马来酸麦角新碱 米索前列醇 宫缩乏力 产后出血 氧化应激 子宫复旧 不良反应 Ergometrine maleate Misoprostol Uterine inertia Postpartum hemorrhage Oxidative stress Uterine involution Adverse reaction
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