腹腔镜胆囊切除术中七氟烷与丙泊酚麻醉效果比较研究

Comparative Study on Anesthetic Effect of Sevoflurane and Propofol in Laparoscopic Cholecystectomy

目的比较分析在腹腔镜胆囊切除术中应用七氟烷与丙泊酚的麻醉效果。方法非随机选取2022年7月—2023年12月苏州市第九人民医院接受腹腔镜胆囊切除术的胆囊结石患者82例,按照治疗方法不同分成两组,各41例。研究组患者应用七氟烷、对照组患者应用丙泊酚,对两组患者的生命体征指标、麻醉苏醒时间、认知功能评分进行比较分析。结果麻醉即刻、切皮后5 min,两组患者生命体征对比,差异有统计学意义(P均<0.05)。研究组自主呼吸恢复时间、苏醒时间、定向力恢复时间均短于对照组,差异有统计学意义(P均<0.05)。术后6、12 h,研究组患者的简易精神状态检查量表评分为(26.15±1.03)分、(26.89±1.10)分,均高于对照组的(24.78±1.19)分、(25.62±1.08)分,差异有统计学意义(t=5.574、5.275,P均<0.05)。结论在胆囊结石患者进行腹腔镜胆囊切除手术治疗时,术中麻醉诱导药物选择七氟烷能够减小生命体征波动,还能加快术后苏醒,减轻认知功能损害。

Objective To compare and analyze the anesthetic effects of sevoflurane and propofol in laparoscopic cholecystectomy.Methods From July 2022 to December 2023,eighty-two patients with gallstones who underwent laparoscopic cholecystectomy in the Ninth People's Hospital of Suzhou City were non-randomly selected.According to different treatment methods,they were divided into two groups with forty-one cases in each group.Sevoflurane was used in the study group and propofol was used in the control group.The vital signs indicators,recovery time of anesthesia and cognitive function score of the two groups were compared and analyzed.Results Immediately after anesthesia and 5 min after skin resection,the vital signs of the two groups were compared,and the differences were statistically significant(both P<0.05).The recovery time of spontaneous respiration,recovery time and recovery time of orientation of the study group after anesthesia was shorter than those of the control group,and the differences were statistically significant(all P<0.05).At 6 h and 12 h after surgery,the MMSE scores of the study group were 26.15±1.03 and 26.89±1.10,respectively,which were higher than 24.78±1.19 and 25.62±1.08 of the control group,and the differences were statistically significant(t=5.574,5.275,both P<0.05).Conclusion When performing laparoscopic cholecystectomy for patients with gallstones,choosing sevoflurane as the anesthesia inducing drug during surgery can reduce fluctuations in vital signs,accelerate postoperative recovery,and alleviate cognitive impairment.