HIV/TB 双重感染者发生免疫重建炎性综合征时血清锌及相关炎症因子的变化特征

Characteristics of changes in serum zinc and related inflammatory factors in HIV/TB co-infected patients during the occurrence of immune reconstitution inflammatory syndrome

目的本研究旨在探讨HIV/TB 双重感染者在抗逆转录病毒治疗(ART)中发生免疫重建炎性综合征(IRIS)后血清中的锌及相关炎症因子的变化情况及临床意义。方法纳入HIV/TB双重感染者83例作为研究对象,进行动态随访,根据患者在ART期间是否发生TB-IRIS分为IRIS组(34例)和no-IRIS组(49例)。还纳入一个对照组,由40名未感染结核的HIV感染者组成。本研究对各组受试者的血清锌水平及相关炎症因子进行了细致的分析与比较。结果IRIS组中的HIV/TB双重感染患者的血清锌浓度低于对照组中的HIV感染者,也低于no-IRIS组中的HIV/TB双重感染患者。结论锌的缺乏可能是结核相关免疫重建炎性综合征(TB-IRIS)发生的一个重要因素,在对HIV/TB 双重感染者进行ART治疗时,应考虑监测和补充锌含量,以改善临床治疗效果。

Objective To investigate the changes in serum zinc and associated inflammatory factors in human immunodeficiency virus/tuberculosis (HIV/TB) co-infected individuals following the development of immune reconstitution inflammatory syndrome (IRIS) during antiretroviral therapy (ART), as well as to assess their clinical implications.Methods A total of 83 patients with co-infection of HIV/TB were involved in this study with follow-up. According to the occurrence of TB/IRIS during ART, the patients were divided into IRIS group (34 cases) and no-IRIS group (49 cases). In addition, healthy individuals without HIV/TB (40 cases) were also enrolled as control. Serum levels of zinc and related inflammatory factors were analyzed and compared between different groups.Results The serum zinc concentration in the IRIS group of HIV/TB co-infected patients was lower than that in the control group of HIV-infected patients and also lower than that in the no-IRIS group of HIV/TB co-infected patients.ConclusionZinc deficiency may be a potential factor in the occurrence of tuberculosis-related immune reconstitution inflammatory syndrome.