心外膜脂肪组织与心房颤动关系的研究进展

Research progress of relationship between epicardial adipose tissue and atrial fibrillation

心外膜脂肪组织是一种位于心脏表面的活跃的内分泌组织,不仅为心脏提供能量,而且还参与炎症反应和代谢调节。心外膜脂肪量的增加与心房颤动(简称房颤)的发病率升高显著相关,其可能通过促进心脏局部炎症、增加氧化应激或直接影响心肌细胞的电生理特性来促进房颤的发生和持续。本文综述了心外膜脂肪组织与房颤之间关系的研究现状,探讨了二者的关联机制,并针对心外膜脂肪组织在房颤发病中的作用提出了未来研究的方向。

Epicardial adipose tissue(EAT) as an active endocrine tissue located on the surface of the heart,not only provides energy for the heart,but also participates in inflammatory responses and metabolic regulation.Increased amount of epicardial adipose is significantly associated with the increased incidence of atrial fibrillation(AF),potentially promoting the occurrence and persistence of AF through mechanisms such as enhancing local cardiac inflammation,increasing oxidative stress,or directly affecting the electrophysiological properties of cardiomyocytes.This paper reviews the current research status on the relationship between EAT and AF,explores their association mechanism,and proposes future research directions regarding the role of EAT in AF pathogenesis.