瞬时受体电位通道香草酸亚型4离子通道在皮肤病中的作用研究

Role of transient receptor potential vanilloid type 4 channel in skin diseases

瞬时受体电位通道香草酸亚型4(TRPV4)是热敏TRPV家族的第4个成员,是一类在全身广泛表达的非选择性阳离子通道,可被多种内外源性介质激活,参与体内各种器官的生理活动。研究显示,TRPV4与皮肤生理病理过程密切相关,主要参与皮肤屏障修复、传导瘙痒感觉等,在玫瑰痤疮、脱发、银屑病、硬皮病、皮肤肿瘤等皮肤病中发挥重要作用。该文综述TRPV4离子通道在皮肤病中的研究进展。

Transient receptor potential vanilloid type 4(TRPV4),the fourth member of the thermosensitive TRPV family,is a nonselective cation channel that is widely expressed in various tissues and cells.TRPV4 is involved in the physiological activities of various organs in the body by responding to both exogenous and endogenous stimuli.Studies have shown that TRPV4 participates in skin physiological and pathophysiological processes,including skin barrier repair and conduction of itch sensation,and also plays important roles in skin disorders,such as rosacea,alopecia,psoriasis,scleroderma,and skin cancer.This review summarizes research progress in the role of TRPV4 channels in skin diseases.