环氧树脂类糊剂加牙胶尖充填根管对牙髓病及根尖周炎患者疼痛及炎症因子水平的影响

Effects of epoxy resin paste plus dental gum tip filling root canal on pain and inflammatory factor levels in patients with pulpitis and periapical periodontitis

目的探讨环氧树脂类糊剂(AH-Plus糊剂)加牙胶尖充填根管对牙髓病及根尖周炎患者疼痛及炎症因子水平的影响。方法选取2023年1月至12月江西省新余市人民医院收治的68例牙髓病及根尖周炎患者作为研究对象,按照随机数字表法分为参照组(34例,患牙44颗)和观察组(34例,患牙45颗)。参照组使用氢氧化钙类糊剂加牙胶尖填充治疗,观察组使用AH-Plus糊剂加牙胶尖根管填充治疗。两组均连续治疗7 d。比较两组临床疗效和治疗前、治疗后疼痛程度、炎症因子水平、牙周指标。结果观察组总有效率高于参照组,差异有统计学意义(P<0.05);治疗后,两组视觉模拟评分法(VAS)评分、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)检测值低于本组治疗前,白细胞介素-4(IL-4)检测值高于本组治疗前,而观察组治疗后IL-4检测值高于参考组,VAS评分、TNF-α、IL-6、hs-CRP检测值低于参考组,差异有统计学意义(P<0.05);治疗后,两组牙周附着丧失(AL)、牙龈出血指数(BI)、牙周袋探诊深度(PD)均低于本组治疗前,而观察组治疗后各指标值低于参考组,差异有统计学意义(P<0.05)。结论牙髓病及根尖周炎患者行AH-Plus糊剂加牙胶尖充填根管治疗疗效更佳,可更好地缓解患者炎症反应,减轻疼痛程度,改善患者牙周状况。

Objective To investigate the effects of epoxy paste AH-Plus paste plus gum tip filling root canal on pain and inflammatory factors in patients with endodontic disease and periapical inflammation.Methods A total of 68 patients with endodontic disease and periapical periodontitis admitted to Xinyu People's Hospital of Jiangxi Province from January to December 2023 were selected as the study objects and they were divided into reference group(34 cases,44 teeth)and observation group(34 cases,45 teeth).The reference group was treated with calcium hydroxide paste plus dental gum tip filling,and the observation group was treated with AH-Plus paste and dental glue for root canal filling.Both groups were treated for 7 days.The clinical efficacy,pain degree,inflammatory factor level and periodontal index of the two groups were compared before and after treatment.Results The total effective rate of the observation group was higher than that of the reference group,and the difference was statistically significant(P<0.05).Visual analogue scale(VAS)score,interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and hypersensitive C-reactive protein(hs-CRP)values after treatment of the two groups were lower than those before treatment,interleukin-4(IL-4)values were higher than those before treatment,and IL-4 values in observation group after treatment were higher than those in reference group,and VAS score,TNF-α,IL-6 and hs-CRP values were lower than those in the reference group,and the differences were statistically significant(P<0.05).After treatment,periodontal attachment loss(AL),gingival bleeding index(BI)and periodontal pocket probing depth(PD)in both groups were lower than before treatment,while after treatment,each index value in observation group was lower than that in reference group,with statistical significance(P<0.05).Conclusion For patients with endodontic disease and periapical inflammation,the effect of filling root canal with AH-Plus paste and gum tip is better,which can better relieve the inflammatory response and reduce the degree of pain,to improve the periodontal status of patients.