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七叶皂苷钠联合鸦胆子油乳治疗恶性胸腔积液的临床观察

Clinical observation of sodium aesculin combined with Bruceau oil emulsion in the treatment of malignant pleural effusion
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摘要 目的:观察七叶皂苷钠注射液联合鸦胆子油乳治疗恶性胸腔积液(Malignant Pleural Effusion,MPE)的临床疗效。方法:选择2020年1月―2022年9月就诊于广州中医药大学附属高州市中医院肿瘤科且符合病例纳入标准的MPE患者60例,随机将MPE患者分为对照组(30例)和观察组(30例)。两组患者签署知情同意书后,进行胸腔闭式引流,注射相应药物,其中对照组给予鸦胆子油乳注射液,观察组在对照组的基础上联合七叶皂苷钠注射液进行治疗。对两组患者的MPE近期疗效、治疗前后中医临床症状及Karnofsky功能状态评分法(Karnofsky Performance Status Scale,KPS)评分进行评价。结果:与治疗前比较,两组MPE患者的疗效、中医临床症状及KPS评分均有所改善,观察组客观有效率(86.67%,26/30)显著高于对照组(63.33%,19/30,P<0.05);两组患者治疗后中医临床症状积分均较治疗前降低(P<0.05),且观察组的中医临床症状积分显著低于对照组(P<0.05),中医临床症状总改善率显著高于对照组(P<0.05);两组MPE患者治疗后KPS评分均较治疗前升高(P<0.05),且观察组的KPS评分、KPS改善率显著高于对照组(P<0.05)。结论:将七叶皂苷钠注射液联合鸦胆子油乳这一方案应用于治疗MPE可有效提高临床疗效,同时改善患者的生活质量,值得临床推广。 Objective:To observe the clinical efficacy of sodium aesculin injection combined with Bruceau oil emulsion in the treatment of malignant pleural effusion(MPE).Methods:A total of 60 patients with MPE who were admitted to the Oncology Department of Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine from January 2020 to September 2022 and met the criteria were selected,and were randomly divided into the control group(30 cases)and the observation group(30 cases).After signing the informed consent letter,MPE patients in the two groups were first given closed thoracic drainage and injected with appropriate medications,among which the control group was given Bruceau oil emulsion injection,and the observation group was treated with sodium aesculin injection on the basis of the treatment in the control group.The MPE shortterm efficacy,TCM clinical symptoms and KPS scores in the two groups were evaluated before and after treatment.Results:Compared with before treatment,the efficacy,TCM clinical symptoms and Karnofsky score of MPE patients in both groups were ameliorated,and the objective effective rate in the observation group(86.67%)was significantly higher than that in the control group(63.33%,P<0.05).The scores of TCM clinical symptoms in both groups were lower after treatment than those before treatment(P<0.05),and the scores of TCM clinical symptoms in the observation group were significantly lower than those in the control group(P<0.05),and the total ameliorated rate of TCM clinical symptoms in the observation group was significantly higher than that in the control group(P<0.05).KPS scores of MPE patients in both groups after treatment were higher than those before treatment(P<0.05),and KPS scores and KPS improvement rates in the observation group were significantly higher than those in the control group(P<0.05).Conclusion:The application of sodium aesculin injection combined with Bruceau oil emulsion can effectively improve the clinical efficacy and promote the quality of life of patients in the treatment of MPE,which is worthy of clinical promotion.
作者 钟启胜 邹汉飞 黎永超 张浒 吕燕海 梁东全 吕玉英 ZHONG Qisheng;ZOU Hanfei;LI Yongchao;ZHANG Hu;LV Yanhai;LIANG Dongquan;LV Yuying
机构地区 高州市中医院
出处 《中医临床研究》 2024年第24期90-93,共4页 Clinical Journal Of Chinese Medicine
基金 茂名市科技计划项目基金(茂科字[2022]24号-2022428)。
关键词 恶性胸腔积液 七叶皂苷钠 鸦胆子油乳 临床疗效 Malignant pleural effusion Sodium aesculin Bruceau oil emulsion Clinical efficacy
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