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体外培育牛黄治疗神经系统疾病的有效性和安全性的Meta分析

Efficacy and Safety of Calculus Bovis Stativus for Neurological Disease:a Meta-Analysis
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摘要 目的:运用Meta分析探究体外培育牛黄(Calculus Bovis Stativus,CBS)治疗神经系统疾病的有效性和安全性。方法:计算机检索PubMed、Web of science、Embase、Cochrane Library、中国知网、万方、维普及中国生物医学等电子数据库中关于CBS治疗神经系统疾病的研究。检索时限为各数据库建库至2024年12月4日。依据纳入排除标准对文献进行筛选,提取相关资料,按照Cochrane系统评价手册推荐的偏倚风险评估工具进行风险评估,使用Rev Man 5.4统计软件进行Meta分析。结果:共纳入5个随机对照研究,共414例患者,Meta分析结果显示,相比于对照组,常规疗法联合CBS组患者血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平显著下降[SMD=-1.40,95%CI(-1.78,-1.01),P<0.001],白细胞介素-6(interleukin-6,IL-6)水平显著下降[SMD=-1.82,95%CI(-2.23,-1.41),P<0.001],格拉斯哥昏迷量表(Glasgow coma scale,GCS)评分得到较强改善[SMD=0.44,95%CI(0.21,0.68),P=0.002],美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分有所下降[SMD=-0.49,95%CI(-0.92,-0.07),P=0.020]。结论:CBS治疗脑卒中相关神经系统疾病有效且安全性较好,但仍需要更多高质量研究进一步支持。 Objective:To explore the efficacy and safety of Calculus Bovis Stativus(CBS)in treating neurological diseases through a meta-analysis.Methods:Electronic databases such as PubMed,Web of Science,Embase,Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang,VIP,and China Biology Medicine disc(CBMdisc)were searched for studies on CBS treatment of neurological diseases.The search period covered from the establishment of each database until December 4,2024.Studies were screened according to inclusion and exclusion criteria,relevant data were extracted,risk assessment was conducted using the bias risk assessment tool recommended by the Cochrane Systematic Review Handbook,and Meta-analysis was performed using Rev Man 5.4 statistical software.Results:A total of five randomized controlled trials involving 414 patients were included.The meta-analysis results showed that compared to the control group,the combination of conventional therapy and CBS significantly reduced tumor necrosis factor-α(TNF-α)levels[SMD=-1.40,95%CI(-1.78,-1.01),P<0.001],significantly reduced interleukin-6(IL-6)levels[SMD=-1.82,95%CI(-2.23,-1.41),P<0.001],improved Glasgow Coma Scale(GCS)scores[SMD=0.44,95%CI(0.21,0.68),P=0.002],and decreased National Institutes of Health Stroke Scale(NIHSS)scores[SMD=-0.49,95%CI(-0.92,-0.07),P=0.02].Conclusion:CBS is effective and safe in treating stroke-related neurological diseases,but more high-quality research is needed for further support.
作者 么瑶 柴诚诚 冉禄森 贺玉琴 方园园 王伟 汪明欢 YAO Yao;CHAI Chengcheng;RAN Lusen;HE Yuqin;FANG Yuanyuan;WANG Wei;WANG Minghuan(Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;School of Instrumentation Science and Optical Engineering,Institute of Large-Scale Scientific Facility Beihang University,Beijing 100089,China;Yunshi International Medical Research(Wuhan)Co.,Ltd.,Wuhan 430073,China)
出处 《神经损伤与功能重建》 2024年第12期683-688,共6页 Neural Injury and Functional Reconstruction
基金 国家自然科学基金项目(星形胶质细胞Cx43调控Glymphatic系统在脑白质缺血后髓鞘修复微环境中的作用,No.81873749)。
关键词 体外培育牛黄 神经系统疾病 脑卒中 META分析 Calculus Bovis Sativus neurological diseases stroke Meta-analysis
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