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Evaluation of the antimicrobial activities and mechanisms of synthetic antimicrobial peptide against food-borne pathogens 被引量:1

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摘要 Food-borne pathogens are an important challenge for the food industry.In this study,the possibility of using the previously designed and synthesized antimicrobial peptide HX-12C as a new food antimicrobial was evaluated.Bacteriostatic and bactericidal tests showed that HX-12C has strong,rapid and broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria.Outer-and inner-membrane permeabilization assays revealed that HX-12C killed food-borne pathogens by inducing membrane permeability.Further Scanning Electron Microscope(SEM)and Transmission Electron Microscope(TEM)also showed that HX-12C can distinctively act on the bacterial membrane leading to the leakage of cellular contents.Moreover,HX-12C also showed anti-biofilm ability in bacterial killing tests.In the food storage test,HX-12C exhibited significant antimicrobial function in raw pork and orange juice.Therefore,HX-12C has shown great potential as a new antimicrobial agent in food storage.
出处 《Food Bioscience》 SCIE 2022年第5期502-511,共10页 食品生物科学(英文)
基金 supported by the National Key Research and Development Program"Intergovernmental International Scientific and Technological Innovation Cooperation"(2021YFE0192100),China The Scientific Research Project of Education Department of Hunan Province(21B0736 and 19A192).
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