MKRN基因家族在疾病中的作用

The role of the MKRN gene family in diseases

makorin无名指蛋白(makorin ring finger protein,MKRN)基因家族编码具有特定锌指结构的蛋白质,在无脊椎动物和有脊椎动物中广泛存在。MKRN(MKRN1、MKRN2、MKRN3、MKRN4)可以通过其特殊的RING结构域,作为E3泛素连接酶与p21、p53、p14ARF、SNIP1和一些细菌蛋白或病毒相互作用并介导其降解,参与细胞周期停滞、心肌细胞凋亡、睾丸发生、造血等多种机体生理过程以及中枢性性早熟、系统性红斑狼疮等许多疾病的调控,尤其与癌症的发生、转移及预后密切相关。本文系统地回顾了MKRN基因家族在疾病发生、发展过程中的作用,并重点描述了其在肿瘤中的作用,提出其可能在未来肿瘤的临床诊断、治疗及预后方面存在巨大潜力。

MKRN(makorin ring finger protein)gene family encodes the proteins with a specific zinc finger structure and are widely found in invertebrates and vertebrates.MKRN(MKRN1,MKRN2,MKRN3,MKRN4)can interact with p21,p53,p14ARF,SNIP1 and some bacterial proteins or viruses through their special RING domains,as E3 ubiquitin ligases and mediate their degradation,and participate in the regulation of various physiological processes such as cell cycle arrest,cardiomyocyte apoptosis,spermatogenesis,hematopoiesis,as well as central precocious puberty,systemic lupus erythematosus and many other diseases.In particular,it is closely related to the occurrence,metastasis and prognosis of cancer.In this review,we systematically reviewed the occurrence and development of the MKRN gene family in the diseases,and focused on its role in tumors,suggesting that it may have great potential in the clinical diagnosis,treatment and prognosis of tumors in the future.