心血管疾病危险因素与乳腺癌之间的相关性分析

Analysis of associations between risk factors for cardiovascular disease and breast cancer

目的探讨心血管疾病危险因素与乳腺癌之间的相关性。方法连续选择2023年1月至2023年6月在上海交通大学医学院附属第九人民医院黄浦分院乳腺外科就诊并接受手术的300例确诊为乳腺癌和300例确诊为乳腺良性疾病的患者。比较两组患者相关心血管疾病危险因素。按照绝经与否进行分层,比较两组不同月经状态患者相关心血管疾病危险因素。采用logistic回归分析乳腺癌相关心血管疾病危险因素。结果两组患者临床及实验室指标差异均有统计学意义(P<0.01)。多因素logistic回归分析显示,年龄(OR=1.03,P=0.029)、三酰甘油(TG;OR=1.94,P=0.025)、C反应蛋白(OR=2.73,P<0.001)、D-二聚体(OR=61.19,P<0.001)和同型半胱氨酸(OR=2.10,P<0.001)是乳腺癌发生独立相关因素。分层分析结果显示,绝经前及绝经后,年龄、TG、C反应蛋白、D-二聚体和同型半胱氨酸均与乳腺癌发生独立相关(P<0.05)。结论心血管疾病危险因素中,年龄增加,TG、C反应蛋白、D-二聚体和同型半胱氨酸水平升高可能导致乳腺癌发生风险增加,有助于筛查乳腺癌高危患者。

Objective To explore the associations between risk factors for cardiovascular disease and breast cancer.Methods A total of 300 patients with breast cancer and 300 with benign breast diseases diagnosed by postoperative pathology were included in the Department of Breast Surgery,Huangpu Branch of the Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine from January 2023 to June 2023.The main cardiovascular risk factors in patients between the two groups were compared.Stratification was performed according to menstrual status,and the main cardiovascular risk factors in patients with different menstrual status between the two groups were compared.The logistic regression correlation analysis was used to analyze the risk factors related to cardiovascular disease for breast cancer.Results There were statistically significant differences in clinical data and laboratory indicators between the two groups(P<0.01).Multivariate logistic regression analysis showed that age(OR=1.03,P=0.029),triglyceride(TG;OR=1.94,P=0.025),C-reactive protein(CRP;OR=2.73,P<0.001),D-dimer(OR=61.19,P<0.001),and homocysteine(Hcy;OR=2.10,P<0.001)were independently associated with breast cancer.The stratified analysis showed age,TG,CRP,D-dimer,and Hcy were independently associated with breast cancer in both premenopausal and postmenopausal patients(P<0.05).Conclusions Among risk factors for cardiovascular disease,advanced age,increased TG,CRP,D-dimer,and Hcy might increase breast cancer risk,which are helpful of screening high-risk individuals for breast cancer.