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连续性血液净化对糖尿病肾病患者肾功能的影响研究

Effect of Continuous Blood Purification on Renal Function in Patients with Diabetic Nephropathy
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摘要 目的分析糖尿病肾病患者治疗期间选用连续性血液净化的效果,评估其对肾功能产生的影响。方法选取2023年7月—2024年6月淄博市中西医结合医院肾病内分泌科收治的60例糖尿病肾病患者为研究对象,按照治疗方法不同分为两组,各30例。对照组采用间歇性血液透析治疗,观察组采用连续性血液净化治疗。比较两组治疗有效率、并发症发生率、血流动力学水平及肾功能。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。治疗前,两组血流动力学指标比较,差异均无统计学意义(P均>0.05);治疗后,观察组心输出量高于对照组,中心静脉压、心率均低于对照组,差异均有统计学意义(P均<0.05)。治疗前,两组肾功能指标比较,差异均无统计学意义(P均>0.05);治疗后,观察组血肌酐、尿素氮水平均低于对照组,差异均有统计学意义(P均<0.05)。结论连续性血液净化应用于糖尿病肾病治疗期间对于调整机体血流动力学水平效果较为理想,可预防术后并发症发生,具有较高的临床应用价值。 Objective To analyze the effect of continuous blood purification during the treatment of diabetic nephropathy patients,and to evaluate its effect on renal function.Methods From July 2023 to June 2024,a total of 60 patients with diabetic nephropathy admitted to the Department of Nephrology and Endocrinology of Zibo Integrated Traditional Chinese and Western Medicine Hospital were selected as the research objects.They were divided into two groups according to different treatment methods,30 cases in each group.The control group was treated with intermittent hemodialysis,and the observation group was treated with continuous blood purification.The effective rate,complication rate,hemodynamic levels and renal function were compared between the two groups.Results The effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in hemodynamic indexes between the two groups(all P>0.05).After treatment,the cardiac output of the observation group was higher than that of the control group,and the central venous pressure and heart rate were lower than those of the control group,the differences were statistically significant(all P<0.05).Before treatment,there were no significant differences in renal function indexes between the two groups(both P>0.05).After treatment,the levels of serum creatinine and urea nitrogen in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).Conclusion The application of continuous blood purification in the treatment of diabetic nephropathy is ideal for adjusting the hemodynamic level of the body,which can prevent postoperative complications and has high clinical application value.
作者 张文文 段聪哲 李菲菲 ZHANG Wenwen;DUAN Congzhe;LI Feifei(Department of Nephrology and Endocrinology,Zibo Integrated Traditional Chinese and Western Medicine Hospital,Zibo 255000,Shandong,China;Department of Medical,Zibo Central Hospital,Zibo 255000,Shandong,China)
出处 《糖尿病新世界》 2024年第20期1-4,共4页 Diabetes New World
基金 淄博市医药卫生项目(20230305018)。
关键词 连续性血液净化 糖尿病肾病 肾功能 Continuous blood purification Diabetic nephropathy Renal function
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