交感神经系统参与骨质疏松发病的研究进展

Research progress on the involvement of the sympathetic nervous system in the pathogenesis of osteoporosis

骨质疏松是全球范围内的重大骨骼健康问题,且骨的神经调控是当前研究领域的重点关注。交感神经系统对骨代谢具有影响作用这一观点已得到大量研究结果的支持,有望为骨质疏松的治疗带来突破性的进展。交感神经张力增高对骨质量以及骨小梁的微结构和功能有害,这一点也已得到证实。然而,交感神经系统参与骨质疏松发病的详细机制尚不明确,其影响骨代谢的具体作用机制仍有待进一步阐明。本文对交感神经系统在骨质疏松发病机制中扮演的角色作一综述,总结交感神经影响骨质疏松的多种分子机制,并从不同角度去观察交感神经在不同类型骨质疏松中的作用,为骨质疏松的防治提供新思路。

Osteoporosis is a major bone health problem in the world,and the neural regulation of bone is the focus of current research.The effect of sympathetic nervous system on bone metabolism has been supported by a large number of research results,which is expected to bring breakthrough progress in the treatment of osteoporosis.It has been established that increased sympathetic nerve tone is harmful to bone quality and the microstructure and function of bone trabeculae.However,the precise mechanisms through which the sympathetic nervous system's contributes to the pathogenesis of osteoporosis remain unclear,and the specific mechanism of its effect on bone metabolism needs to be further clarified.This article reviews the role of the sympathetic nervous system in the pathogenesis of osteoporosis,summarizes the molecular mechanisms of the sympathetic nerve affecting osteoporosis,and investigates the role of the sympathetic nerve in different types of osteoporosis from different angles,thereby providing new insights for the prevention and treatment of osteoporosis.