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苓桂术甘汤联合沙库巴曲缬沙坦治疗慢性心力衰竭的临床观察

Clinical observation of Linggui Zhugan decoction combined with sacubitril valsartan in the treatment of chronic heart failure
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摘要 目的探究苓桂术甘汤联合沙库巴曲缬沙坦在慢性心力衰竭(chronic heart failure,CHF)患者中的疗效。方法将124例于2022年1月至2023年5月本院收治的CHF患者随机分为对照组(n=62,采用沙库巴曲缬沙坦进行治疗)及观察组(n=62,苓桂术甘汤+沙库巴曲缬沙坦),比较两组临床疗效、超声心动图参数、血清学指标、血管内皮功能和不良反应。结果观察组总有效率高于对照组(98.39%vs 80.65%,P<0.05)。两组治疗后左心室舒张末内径均较治疗前下降,左心室射血分数上升,且观察组改善幅度优于对照组(P<0.05)。治疗后,两组白介素-6、亲环素A、肿瘤坏死因子-α、N末端脑利钠肽前体水平均较治疗前下降,且观察组低于对照组(P<0.05);治疗后,两组一氧化氮均较治疗前升高、内皮素-1较治疗前降低,且观察组改善幅度优于对照组(P<0.05)。观察组不良反应发生率低于对照组(3.23%vs 16.13%,P<0.05)。结论苓桂术甘汤联合沙库巴曲缬沙坦能够有效提高CHF患者临床疗效,改善超声心动图参数、血清学指标和血管内皮功能,且安全性更佳。 Objective To explore the efficacy of Linggui Zhugan decoction combined with sacubitril valsartan in patients with chronic heart failure(CHF).Methods A total of 124 patients with CHF admitted to our hospital from January 2022 to May 2023 were randomly divided into the control group(n=62,treated with sacubitril valsartan)and the observation group(n=62,Linggu Zhugan decoction+sacubitril valsartan).The clinical efficacy,echocardiographic parameters,serological parameters,vascular endothelial function and adverse reactions were compared between the two groups.Results The total effective rate of observation group was higher than that of control group(98.39%vs 80.65%,P<0.05).After treatment,left ventricular end-diastolic diameter decreased and left ventricular ejection fraction increased in both groups,and the improvement in the observation group was better than that in the control group(P<0.05).After treatment,the levels of interleukin-6,cyclophilin A,tumor necrosis factor-αand N-terminal brain natriuretic peptide precursor in both groups were decreased compared with those before treatment,and the improvement in the observation group was better than that in the control group(P<0.05).After treatment,nitric oxide was increased and endothelin-1 was decreased in both groups,and the improvement in the observation group was better than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(3.23%vs 16.13%,P<0.05).Conclusion Linggui Zhugan decoction combined with sacubitril valsartan can effectively improve the clinical efficacy of CHF patients,improve echocardiographic parameters,serological indexes and vascular endothelial function,and has better security.
作者 陆强 南岳龙 郭晓平 张晓亮 孙东辉 韩文忠 LU Qiang;NAN Yuelong;GUO Xiaoping;ZHANG Xiaoliang;SUN Donghui;HAN Wenzhong(Department of Second Cardiovascular Diseases,Cangzhou Hospital of Integrated TCM WM Hebei,Cangzhou 061000,Hebei Province,China;Department of Cardiology,Cangzhou Hospital of Integrated TCM WM Hebei,Orthopedic Hospital Area,Cangzhou 061000,Hebei Province,China;Department of Interventional Medicine,Cangzhou Hospital of Integrated TCM WM Hebei,Cangzhou 061000,Hebei Province,China)
出处 《世界临床药物》 CAS 2024年第11期1155-1160,1211,共7页 World Clinical Drug
基金 河北省中医药管理局科研计划项目(2022261)。
关键词 苓桂术甘汤 沙库巴曲缬沙坦 慢性心力衰竭 Linggui Zhugan decoction sacubitril valsartan chronic heart failure
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