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鳖甲煎丸对肝硬化的治疗效果及TNF-α、IL-6水平影响分析

Analysis of Curative Effect of Turtle Shell Pills on Liver Cirrhosis and Influence of TNF-αand IL-6 Levels
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摘要 目的探究鳖甲煎丸对肝硬化的治疗效果及对肿瘤坏死因子-α、白细胞介素-6水平的影响。方法选取2022年6月—2023年6月无锡市新吴区新瑞医院收治的肝硬化患者88例为研究对象,按照随机数字表法将其分为两组,每组44例。对照组采用恩替卡韦治疗,观察组联用鳖甲煎丸治疗,比较两组肝功能、炎症因子、肝纤维化指标、治疗效果。结果治疗后,观察组谷草转氨酶、谷丙转氨酶、总胆红素低于对照组(P<0.05);观察组肿瘤坏死因子-α、超敏C反应蛋白、白细胞介素-6、白细胞介素-1β低于对照组(P<0.05);观察组Ⅲ型前胶原Ⅳ型胶原、透明质酸、层黏蛋白低于对照组(P<0.05);观察组治疗总有效率高于对照组(χ^(2)=4.456,P=0.035)。结论采用鳖甲煎丸对肝硬化进行治疗,能够有效改善患者的肝功能指标、降低炎症因子水平、优化肝纤维化指标,进而提升整体治疗效果。 Objective To investigate curative effect of turtle shell pills on liver cirrhosis and influence of tumor necrosis factor-αand interleukin-6 levels.Methods The paper chose 88 patients with liver cirrhosis in Wuxi City Xinwu District Xinrui Hospital from June 2022 to June 2023 as study subjects,and divided them into two groups with random number table method,with 44 cases in each group.The control group was treated with entecavir,while the observation group with turtle shell pills.The liver function,inflammatory factors,liver fibrosis indicators,and treatment effect were compared between two groups.Results After treatment,levels of aspartate aminotransferase,alanine aminotransferase,and total bilirubin in the observation group were lower than the control group(P<0.05).Levels of tumor necrosis factor-α,high-sensitivity C-reactive protein,interleukin-6,and interleukin-1βin the observation group were lower than the control group(P<0.05).Levels of typeⅢprocollagen,typeⅣcollagen,hyaluronic acid,and laminin in the observation group were lower than the control group(P<0.05).Total effective rate of the observation group treatment was 97.73%,higher than 81.82%in the control group(χ^(2)=4.456,P=0.035).Conclusion Turtle shell pills can improve liver function,inflammatory factors,liver fibrosis indicators and enhance curative effect of liver cirrhosis.
作者 赵书菡 陈丽叶 潘海元 ZHAO Shuhan;CHEN Liye;PAN Haiyuan(Pharmacy Department,Wuxi City Xinwu District Xinrui Hospital,Wuxi,Jiangsu 214145;Pharmacy Department,Kunshan City Traditional Chinese Medicine Hospital,Kunshan 215399,Jiangsu)
出处 《智慧健康》 2024年第28期49-52,共4页 Smart Healthcare
关键词 肝硬化 鳖甲煎丸 恩替卡韦 肝功能 炎症因子 肝纤维化 Liver cirrhosis Turtle shell pills Entecavir Liver function Inflammatory factors Hepatic fibrosis
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