摘要
目的探讨参芪固本汤治疗婴幼儿哮喘缓解期肺脾气虚证的临床效果。方法选取2020年3月至2022年3月于扬州大学医学院附属淮安市妇幼保健院收治的哮喘缓解期肺脾气虚证婴幼儿67例,按随机数字表法分为常规组(34例)、试验组(33例)。常规组采用吸入糖皮质激素(ICS)治疗,试验组采用参芪固本汤+ICS治疗。两组均连续治疗6个月,比较两组治疗总有效率,分别于治疗前、治疗6个月观察中医证候评分、改良中文版儿童呼吸和哮喘控制测试(TRACK)评分、肺功能[达峰时间/呼气时间(TPTEF/TE)、达峰容积/呼气量(VPEF/VE)]、嗜酸性粒细胞(EOS)、白介素-6(IL-6)、免疫球蛋白E(IgE)。结果治疗6个月,试验组中医证候评分较入组时降低,改良中文版TRACK评分升高,差异有统计学意义(P<0.05)。两组治疗6个月中医证候评分、改良中文版TRACK评分比较,差异无统计学意义(P>0.05)。治疗6个月,试验组肺功能(TPTEF/TE、VPEF/VE)水平升高,差异有统计学意义(P<0.01),且试验组TPTEF/TE、VPEF/VE水平高于常规组,差异有统计学意义(P<0.05)。治疗6个月,试验组EOS计数、IL-6、IgE与入组时比较均下降,差异有统计学意义(P<0.05);且试验组与常规组IgE水平组间比较,差异有统计学意义(P<0.05)。结论参芪固本汤联合ICS在治疗婴幼儿哮喘缓解期肺脾气虚证方面较单纯西药治疗有优势。
Objective To explore the clinical effect of Shenqi Guben Decoction in the treatment of infants with lungspleen qi deficiency syndrome in the remission stage of asthma.Methods A total of 67 infants with lungspleen qi deficiency syndrome in the remission stage of asthma admitted to Huai’an Maternal and Child Health Care Hospital Affiliated to Yangzhou University from March 2020 to March 2022 were selected and divided into a conventional group of 34 cases and an experimental group of 33 cases according to the random number table method.The conventional group was treated with inhaled corticosteroid(ICS),and the experimental group was treated with Shenqi Guben Decoction+ICS.The two groups were treated for 6 months,the total effective rate of treatment was compared between the two groups,and the traditional Chinese medicine(TCM)syndrome score,the modified Chinese version of test for respiratory and asthma control in kids(TRACK)score,lung function(time to peak tidal expiratory flow/expiratory time[TPTEF/TE],volume at peak tidal expiratory flow/exhaled volume[VPEF/VE]),eosinophil(EOS),interleukin-6(IL-6),and immunoglobulin E(IgE)were observed before treatment and six months of treatment.Results At six months of treatment,the TCM syndrome score of the experimental group was lower than that at the time of enrollment,the modified Chinese version of the TRACK score was higher than that at the time of enrollment,and the differences were statistically significant(P<0.05).Comparison of TCM syndrome score and modified Chinese version of TRACK score between the two groups at six months of treatment showed no statistically significant difference(P>0.05).At six months of treatment,the levels of pulmonary function(TPTEF/TE and VPEF/VE)increased in the experimental group,with statistically significant differences(P<0.01),and the levels of TPTEF/TE and VPEF/VE in the experimental group were higher than those in the conventional group,with statistically significant differences(P<0.05).At six months of treatment,the EOS count,IL-6,and IgE of the experimental group decreased compared with those at the time of enrollment,and the differences were statistically significant(P<0.05).The difference in IgE level was statistically significant between the experimental group and the conventional group(P<0.05).Conclusion Shenqi Guben Decoction combined with ICS has advantages over western medicine alone in the treatment of infants with lung-spleen qi deficiency syndrome in the remission stage of asthma.
作者
任太亮
林小飞
刘成全
徐妍
宋忠瑞
欧明明
REN Tailiang;LIN Xiaofei;LIU Chengquan;XU Yan;SONG Zhongrui;OU Mingming(Department of Pediatrics,Huai’an Maternal and Child Health Care Hospital Affiliated to Yangzhou University,Jiangsu Province,Huai’an 223002,China;Department of Traditional Chinese Medicine,Huai’an Maternal and Child Health Care Hospital Affiliated to Yangzhou University,Jiangsu Province,Huai’an 223002,China;Department of Neonatology,Huai’an Maternal and Child Health Care Hospital Affiliated to Yangzhou University,Jiangsu Province,Huai’an 223002,China;Neonatal Disease Screening Center,Huai’an Maternal and Child Health Care Hospital Affiliated to Yangzhou University,Jiangsu Province,Huai’an 223002,China)
出处
《妇儿健康导刊》
2024年第23期193-198,F0003,共7页
JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE
基金
江苏省中医药科技发展计划项目(YB2020076)。
关键词
婴幼儿
哮喘
缓解期
参芪固本汤
Infant
Asthma
Remission stage
Shenqi Guben Decoction