喜炎平注射液联合布地奈德雾化吸入治疗儿童肺炎支原体肺炎的效果及对IL-6、TNF-α水平的影响

Effect of Xiyanping Injection Combined with Budesonide Atomization Inhalation in the Treatment of Mycoplasmal Pneumoniae Pneumonia in Children and Its Influence on the Levels of IL-6 and TNF-α

目的:探究在肺炎支原体肺炎患儿中采用喜炎平注射液联合布地奈德雾化吸入治疗的价值。方法:选取2022年1月—2023年12月在新余市妇幼保健院接受治疗的103例肺炎支原体肺炎患儿作为研究对象,采用随机数字表法分为对照组(n=51,给予布地奈德雾化吸入治疗)、研究组(n=52,在对照组的基础上联合喜炎平注射液治疗),同时两组均予以大环内酯类抗生素抗感染。对比两组临床疗效、炎症因子、免疫因子、不良反应发生情况。结果:研究组的总有效率(96.15%)高于对照组(84.31%),差异有统计学意义(χ^(2)=4.118,P=0.042);治疗后,研究组的超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、CD8^(+)均低于对照组,CD4^(+)高于对照组,差异均有统计学意义(P<0.05);研究组不良反应发生率(3.85%)与对照组(9.80%)比较,差异无统计学意义(χ^(2)=1.443,P=0.230)。结论:对儿童肺炎支原体肺炎采取喜炎平注射液联合布地奈德雾化吸入治疗有利于改善患儿的炎症因子和免疫因子水平,提高临床效果,且安全性较高。

Objective:To explore the value of Xiyanping Injection combined with Budesonide atomization inhalation in the treatment of children with Mycoplasmal pneumoniae pneumonia.Method:A total of 103 children with Mycoplasmal pneumoniae pneumonia who received treatment in Maternity&Child Care Center of Xinyu from January 2022 to December 2023 were selected as the study objects,and were divided into control group(n=51,given Budesonide atomization inhalation therapy)and study group(n=52,combined with Xiyanping Injection on the basis of control group)by random number table method.At the same time,both groups were given macrolides antibiotic for anti-infection.The clinical efficacy,inflammatory factors,immune factors and adverse reactions were compared between the two groups.Result:The total effective rate of the study group(96.15%)was higher than that of the control group(84.31%),the difference was statistically significant(χ^(2)=4.118,P=0.042).After treatment,the levels of hypersensitive C reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and CD8^(+)in the study group were lower than those in the control group,and CD4^(+)was higher than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the study group(3.85%)and the control group(9.80%)(χ^(2)=1.443,P=0.230).Conclusion:Xiyanping Injection combined with Budesonide atomization inhalation therapy for children with Mycoplasmal pneumoniae pneumonia is beneficial to improve the levels of inflammatory factors and immune factors,improve the clinical efficacy,and have high safety.