TV-CDFI指标联合FAR、D-D预测卵巢癌手术预后价值

Predictive value of the transvaginal color Doppler flow imaging combined with the fibrinogen/albumin ratio and the D-dimer level of patients for their prognosis after ovarian cancer surgery

目的:探究经阴道彩色多普勒血流成像(TV-CDFI)指标联合血纤维蛋白原/白蛋白比值(FAR)、D-二聚体(D-D)对卵巢癌手术预后的预测价值。方法:选取2015年1月-2021年1月本院接受手术治疗的227例卵巢癌患者,术后进行3年随访,统计患者预后情况,分析卵巢癌患者预后影响因素,评价TV-CDFI测定血流指标、FAR、D-D对卵巢癌预后的预测价值。结果:随访3年,227例卵巢癌患者中,失访15例,共212例(93.4%)完成随访,复发82例,复发率38.7%(82/212),中位复发时间11(8,15)个月。COX回归分析显示,肿瘤分期Ⅲ~Ⅳ期、淋巴结转移、TV-CDFI指标异常、FAR升高、D-D升高均为卵巢癌预后影响因素(P<0.05);绘制受试者工作特征曲线显示,TV-CDFI指标、FAR、D-D预测卵巢癌手术预后的曲线下面积(AUC)均≥0.7,各指标联合预测时AUC为0.983,预测效能更高。结论:卵巢癌术前患者TV-CDFI血流指标异常、血FAR升高、血D-D升高均与不良预后有关,临床检测其水平有助于预测卵巢癌手术预后,为临床治疗提供参考。

Objective:To explore the predictive value of the transvaginal color Doppler flow imaging(TV-CDFI)combined with the fibrinogen/albumin ratio(FAR)and the D-dimer(D-D)level of patients for their prognosis after the ovarian cancer surgery.Methods:A total of 227 patients with ovarian cancer who had undergone surgical treatment from January 2015 to January 2021 were selected and were followed up for 3 years after operation.The prognosis of the patients was counted.The prognostic influence factors of the patients with the ovarian cancer surgery were analyzed.The predictive value of the blood flow indexes measured by TV-CDFI,the FAR and the D-D level of the patients with ovarian cancer surgery for their prognosis was evaluated.Results:After 3 years of follow-up,15 of the 227 patients with ovarian cancer were lost to follow-up.A total of 212(93.4%)patients had completed the follow-up,and among them,there were 82 cases with ovarian cancer recurred,with a recurrence rate of 38.7%(82/212),and the median recurrence time of the patients with the ovarian cancer recurrence was 11(8,15)months.COX regression analysis showed that the ovarian cancer stage Ⅲ-Ⅳ,the lymph node metastasis,the abnormal blood flow index measured by TV-CDFI,and the increased FAR and the D-D level of the patients were all the factors affecting their prognosis after ovarian cancer surgery(P<0.05).Receiver operator characteristic(ROC)curve showed that the area under the curve(AUC)of the blood flow index measured by TV-CDFI,the FAR and the D-D level of the patients with the ovarian cancer surgery for predicting their prognosis were all≥0.7,and the AUC of the combined the blood flow index measured by TV-CDFI,the FAR and the D-D level of the patients with the ovarian cancer surgery for predicting their prognosis was 0.983,and which was the highest.Conclusion:The abnormal blood flow indexes measured by TV-CDFI,and the increased FAR and the D-D level of the patients are all related to their prognosis.The of the blood flow indexes measured by TV-CDFI,and the detections of the FAR and the D-D level of the patients are helpful to predict their prognosis after ovarian cancer surgery and can provide the reference for the clinical treatment.