摘要
目的:探讨妊娠并发甲状腺功能减退(甲减)患者血清甲状腺过氧化物酶抗体(TPOAb)、转化生长因子-β(TGF-β)水平及对母婴不良结局的影响。方法:回顾性收集2021年11月-2023年3月本院治疗的妊娠并发甲减患者92例临床资料纳入病例组,产前检查健康孕妇46例为对照组。比较两组孕20周时血清TPOAb、TGF-β、水平,分析妊娠并发甲减患者发生不良母婴结局的危险因素,受试者工作特征(ROC)曲线分析血清TPOAb、TGF-β评估妊娠并发甲减患者发生不良母婴结局价值。结果:病例组TPOAb水平(394.26±54.65U/ml)高于对照组(19.21±9.13 U/ml),TGF-β水平(268.79±89.65ng/L)低于对照组(381.23±98.45ng/L),不良母婴结局总发生率(29.4%)高于对照组(8.7%),病例组中母婴结局不良组血清TPOAb水平高于良好组,TGF-β水平低于良好组(均P<0.05)。logistic回归分析,TPOAb升高、TGF-β水平降低是妊娠并发甲减患者不良母婴结局发生的危险因素(P<0.05);ROC曲线分析,血清TPOAb、TGF-β预测母婴不良结局均有价值,2项联合预测的曲线下面积(0.915)高于单项指标(P<0.05)。结论:妊娠并发甲减患者血清TPOAb水平升高、TGF-β水平降低,这两个指标是患者发生不良母婴结局的危险因素,且联合预测母婴不良结局有较高临床价值。
Objective:To exploring the thyroid peroxidase antibody(TPOAb)and transforming growth factor-β(TGF-β)levels of pregnant women with hypothyroidism,and to study their influence on the maternal and fetal adverse outcomes.Methods:The clinical data of 92 pregnant women with hypothyroidism from November 2021 to March 2023 were selected in study group retrospectively.And another 46 healthy pregnant women who came to the hospital for prenatal examination during the same period were selected in control group.The levels of TPOAb and TGF-β of the women during 20 gestational weeks were compared between two groups,The risk factors of the maternal and infant adverse outcomes of the pregnant women with hypothyroidism were analyzed.Receiver operating characteristic(ROC)curve was used to analyze the value of the serum TPOAb and TGF-β levels of the pregnant women with hypothyroidism for evaluating the maternal and infant adverse outcomes.Results:The level of TPOAb(394.26±54.65 U/ml)of the women in the study group was significantly higher than that(19.21±9.13 U/ml)of the women in the control group,and the level of TGF-β(268.79±89.65 ng/L)of the women in the study group was significantly lower than that(381.23±98.45 ng/L)of the women in the control group.The total incidence of the maternal and infant adverse outcomes(29.4%)of the women in the study group was significantly higher than that(8.7%)of the women in the control group.In the study group,the serum TPOAb level of the women with the poor maternal and infant outcomes was significantly higher than that of the women with the normal maternal and infant outcomes,but the TGF-β level of the women with the poor maternal and infant outcomes was significantly lower(all P<0.05).Logistic regression analysis showed that the increase of the TPOAb level and the decrease of the TGF-β level of the pregnant women with hypothyroidism were the risk factors of their maternal and infant adverse outcomes(P<0.05).ROC curve analysis showed that serum TPOAb and TGF-β levels of the pregnant women with hypothyroidism had value for predicting the maternal and infant adverse outcomes.The area under the curve of the combined serum TPOAb and TGF-β levels of the pregnant women with hypothyroidism had value for predicting the maternal and infant adverse outcomes was 0.915,and which was significantly higher than that of the serum TPOAb level or the TGF-β level alone(P<0.05).Conclusion:The serum TPOAb level of the pregnant women with hypothyroidism increases and the TGF-β level of them decreases,and both of which are the risk factors of the maternal and infant adverse outcomes.The combination of the serum TPOAb and TGF-β levels of the pregnant women with hypothyroidism has higher clinical value for predicting the maternal and infant adverse outcomes.
作者
朱雨露
徐岚
任萍
ZHU Yulu;XU Lan;REN Ping(The Affiliated Hospital of Jiangnan University,Wuxi,Jiangsu Province,214000;The First Affiliated Hospital of Shantou University Medical College,Shantou,Guangdong Province)
出处
《中国计划生育学杂志》
2024年第12期2910-2914,共5页
Chinese Journal of Family Planning
关键词
妊娠并发甲状腺功能减退
甲状腺过氧化物酶抗体
转化生长因子-Β
母婴不良结局
影响因素
预测
Pregnancy complication with hypothyroidism
Thyroid peroxidase antibody
Transforming growth factorbeta
Maternal and infant adverse outcomes
Influencing factor
Prediction