经颅超声刺激在神经康复中应用的文献计量分析

Application of transcranial ultrasound stimulation in neurorehabilitation:a bibliometric analysis

目的 分析经颅超声刺激(TUS)在神经康复中应用的发展现状、研究热点和发展趋势。方法 检索自建库至2023年12月31日中国知网、万方数据库和Web of Science核心合集数据库中关于TUS在神经康复领域应用的相关文献。采用VOSviewer 1.6.20和CiteSpace 6.2.R1进行可视化分析。结果 共纳入247篇文献,其中中文124篇,英文123篇,年发文量总体呈上升趋势。中国、美国、加拿大、法国和韩国为英文文献的高产国家。中文高频关键词包括经颅超声、神经调控、帕金森病、脑卒中、临床疗效;形成的关键词聚类包括经颅超声、神经调控、上肢功能和帕金森病;出现的突现词包括康复、神经功能、超声治疗、闭环控制、低强度。英文高频关键词包括聚焦超声、深部脑刺激、经颅磁刺激、血脑屏障、丘脑切开术;形成的关键词聚类涉及组织型纤溶酶原激活物、超声波成像、经颅磁刺激、丘脑切开术、超声;出现的突现词有特发性震颤、神经刺激、直流电刺激和经颅超声刺激。结论 TUS在神经康复中应用的相关研究呈上升趋势,主要关注其在帕金森病、特发性震颤和缺血性脑卒中的有效性和安全性。未来研究需深入探讨TUS的机制,优化治疗方案,并促进个性化治疗的发展。

Objective To analyze the current status,research hotspots,and development trends of transcranial ultrasound stimulation(TUS)in neurorehabilitation.Methods Relevant literature on the application of TUS in neurological rehabilitation was retrieved from CNKI,Wanfang data,and Web of Science Core Collection,covering publications from inception to December 31,2023.VOSviewer 1.6.20 and CiteSpace 6.2.R1 were used for visualized analysis.Results A total of 247 articles were included,with 124 in Chinese and 123 in English,showing an increasing trend in annual publications.The major contributors to English literature were China,the United States,Canada,France and South Korea.High-frequency Chinese keywords included transcranial ultrasound,neuromodulation,Parkinson's disease,stroke and clinical efficacy.The keyword clusters were transcranial ultrasound,neuromodulation,upper limb function and Parkinson's disease.Bursting keywords included rehabilitation,neural function,ultrasound therapy,closed-loop control and low intensity.High-frequency English keywords included focused ultrasound,deep brain stimulation,transcranial magnetic stimulation,blood-brain barrier and thalamotomy.Keyword clusters covered tissue plasminogen activator,ultrasonic imaging,transcranial magnetic stimulation,thalamotomy and ultrasound.Bursting keywords featured essential tremor,neurostimulation,direct current stimulation and transcranial ultrasound stimulation.Conclusion Research on the application of TUS in neurorehabilitation is on the rise,focusing on its efficacy and safety in Parkinson's disease,essential tremor,and ischemic stroke.Future research needs to explore the mechanisms of TUS,optimize treatment plans,and promote the development of individualized therapies.