全息血管硬度分析技术评估桥本氏甲状腺炎患者颈动脉僵硬度的临床价值

Clinical value of RF-data based quantitative analysis on vessel stiffness in the evaluation of carotid artery stiffness in patients with Hashimoto’s thyroiditis

目的应用全息血管硬度分析技术(R-VQS)评估桥本氏甲状腺炎(HT)患者颈动脉僵硬度,探讨其临床应用价值。方法选取于我院就诊的73例HT女性患者,按甲状腺功能正常与否分为异常组38例和正常组35例,另选同期50例正常女性为对照组,比较各组一般资料、血清学指标及颈总动脉超声参数的差异。分析颈总动脉超声参数与一般资料及血清学指标的相关性;评价观察者内和观察者间测量颈总动脉超声参数的一致性。结果各组收缩压、舒张压、脉压及高密度脂蛋白比较差异均有统计学意义(均P<0.05)。各组颈总动脉收缩期直径(SD)、硬度指数(SI)及脉搏波传导速度(PWV)比较差异均有统计学意义(均P<0.05),内-中膜厚度(IMT)和血管壁位移(VWD)比较差异均无统计学意义。颈总动脉SI与收缩压、脉压均呈正相关,与高密度脂蛋白呈负相关(均P<0.05);PWV与收缩压、脉压均呈正相关,与舒张压、高密度脂蛋白均呈负相关(均P<0.05)。观察者间和观察者内测量颈总动脉SD、SI、PWV、IMT、VWD的一致性均好(均P<0.05)。结论R-VQS可较好地评估HT患者颈动脉僵硬度,有助于及时发现颈动脉病变,具有一定的临床应用价值。

Objective To explore the clinical application value of RF-data based quantitative analysis on vessel stiffness(R-VQS)in the evaluation of carotid artery stiffness in patients with Hashimoto’s thyroiditis(HT).Methods A total of 73 female patients with HT were selected from our hospital and divided into two groups according to thyroid function:the abnormal thyroid function HT group(n=38)and the normal thyroid function HT group(n=35).50 age-matched healthy females were included as control group.The differences of general data,serum indicators and carotid artery ultrasonic parameters among groups were compared.The correlation between carotid artery ultrasonic parameters and general data,serum indicators were analyzed,the repeatability test was used to evaluate the consistency of carotid ultrasonic parameters measured by inter-and intra-observer.Results There were significant differences in systolic blood pressure,diastolic blood pressure,pulse pressure and high-density lipoprotein among groups(all P<0.05).There were significant differences in common carotid artery systolic diameter,stiffness index and pulse wave velocity among groups(all P<0.05),while the comparison of intima-media thickness and vessel wall displacement showed no statistical difference.Correlation analysis showed that common carotid artery systolic diameter was positively correlated with systolic blood pressure,pulse pressure,and negatively correlated with high-density lipoprotein(all P<0.05).Pulse wave velocity was positively correlated with systolic blood pressure and pulse pressure,and negatively correlated with diastolic blood pressure and high-density lipoprotein(all P<0.05).The inter-and intra-observer consistency of the measurement of common carotid artery parameters such as systolic diameter,stiffness index,pulse wave velocity,intima-media thickness,vessel wall displacement were good(all P<0.05).Conclusion R-VQS can evaluate carotid artery stiffness and carotid artery lesions in HT patients effectively,which has a certain clinical application value.