外泌体microRNA在初治肺结核患者诊疗中的研究进展

Research Progress on Exosome MicroRNA in the Diagnosis and Treatment of Patients with Newly Treated Pulmonary Tuberculosis

结核病是结核分枝杆菌引起的慢性传染性疾病,是全球公共卫生领域的重大挑战,而我国则是结核病高负担国家之一。结核病虽可累及全身,但仍以肺结核最常见,初治肺结核(newly diagnosed pulmonary tuberculosis,PPTB)的早期诊断和有效治疗对于结核病的控制和减轻患者、社会疾病负担至关重要。近年来,外泌体及其携带的微小RNA(miRNA)在肺部疾病诊疗中的应用取得明显进展,也为PPTB的临床诊疗提供了新思路。我们旨在对外泌体miRNA在初治PTB患者诊疗中的应用进展进行阐述,以期为PPTB的诊疗提供参考。

Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis(Mycobacterium tuberculosis,MTB)and a major challenge in the global public health field.China is one of the countries with high burden of tuberculosis.Although tuberculosis can affect the whole body,pulmonary tuberculosis(pulmonary tuberculosis,PTB)is still the most common.Early diagnosis and effective treatment of newly diagnosed pulmonary tuberculosis(newly diagnosed pulmonary tuberculosis,PPTB)are crucial to control tuberculosis and reduce the burden of patients and social diseases.In recent years,the application of extracellular vesicles and their carried microRNA(miRNA)in the diagnosis and treatment of lung diseases has made significant progress,providing new ideas for the clinical diagnosis and treatment of PPTB.This article aims to elaborate on the application progress of extracellular vesicle miRNA in the diagnosis and treatment of newly diagnosed pulmonary tuberculosis patients,in order to provide reference for the diagnosis and treatment of PPTB.