缬沙坦联合不同剂量阿托伐他汀治疗高血压的临床研究

Clinical Study of Valsartan Combined with Different Doses of Atorvastatin in the Treatment of Hypertension

目的研究缬沙坦联合不同剂量阿托伐他汀治疗高血压的临床疗效。方法选取焦作卫生医药学校附属医院2021年1月至2023年8月期间收治的82例高血压患者,按随机数表法分为两组,各41例。对照组给予缬沙坦联合低剂量(20 mg/d)阿托伐他汀治疗,研究组采用缬沙坦联合高剂量(40 mg/d)阿托伐他汀治疗,两组均治疗12周。比较两组临床疗效,治疗前与治疗12周后血压水平[收缩压(SBP)、舒张压(DBP)]、炎症反应[超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、血管内皮功能[一氧化氮(NO)、内皮素-1(ET-1)]的变化情况,并统计不良反应。结果研究组治疗有效率(97.56%)高于对照组(80.49%),差异具有统计学意义(P<0.05);治疗12周后,两组血清hs-CRP、IL-6、TNF-α、SBP、DBP、ET-1水平均显著降低,而NO水平显著升高,且研究组上述指标改善幅度较大,差异均有统计学意义(P<0.05);研究组不良反应发生率(4.88%)与对照组(9.76%)相比,差异无统计学意义(P>0.05)。结论缬沙坦联合高剂量(40 mg/d)阿托伐他汀治疗高血压疗效较好,可有效控制血压水平,减轻炎症反应,改善血管内皮功能,安全性较好。

Objective To investigate the clinical efficacy of valsartan combined with different doses of atorvastatin in the treatment of hypertension.Methods A total of 82 patients with hypertension who were treated at the Affiliated Hospital of Jiaozuo Health and Medicine College from January 2021 to August 2023 were selected and randomly divided into two groups,with 41 cases in each group.The control group received valsartan combined with low-dose(20 mg/d)atorvastatin treatment,while the study group received valsartan combined with high-dose(40 mg/d)atorvastatin treatment,with both groups undergoing treatment for 12 weeks.The clinical efficacy,blood pressure levels[systolic blood pressure(SBP),diastolic blood pressure(DBP)],inflammatory responses[high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α)],and endothelial function[nitric oxide(NO),endothelin-1(ET-1)]before and after 12 weeks of treatment were compared,and adverse reactions were recorded.Results The effective rate of treatment in the study group(97.56%)was higher than that in the control group(80.49%),with a statistically significant difference(P<0.05).After 12 weeks of treatment,the serum levels of hs-CRP,IL-6,TNF-α,SBP,DBP,and ET-1 in both groups significantly decreased,while the level of NO significantly increased.The study group showed a greater improvement in these indicators,and the differences were statistically significant(P<0.05).The incidence rate of adverse reactions in the study group(4.88%)was not significantly different from that in the control group(9.76%)(P>0.05).Conclusion Valsartan combined with high-dose(40 mg/d)atorvastatin is effective in treating hypertension,effectively controlling blood pressure levels,reducing inflammatory responses,and improving endothelial function,with good safety.