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Nature-skin-derived multi-responsive e-skin as on-demand drug-delivery system facilitated melanoma postoperative therapy

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摘要 An ideal strategy for integrated melanoma treatment involves the pursuit of multifunctional biomaterials that possess adjuvant therapy functions,enabling full-scale postoperative relapse prevention,wound healing,and real-time postoperative surveillance.The simulation of electronic skin(e-skin),which emulates the mechanical properties and functions of natural skin,holds significant potential for broad biomedical applications.Herein,a novel multi-responsive controlled-release e-skin(PADM-MX-Ag-Si@Dox)was developed using natural porcine dermal matrix,MXene nanosheets,silver nanowires(AgNWs),and mesoporous hollow silica microspheres(TSOHSiO_(2)@Dox)for drug-loading.The resulting e-skin exhibited temperature-,pH-,and electric-responsiveness due to the incorporation of TSOHSiO_(2)@Dox microspheres,which allowed for on-demand controlled-release of Dox.The biomimetic structure of porcine acellular dermal matrix(PADM)can significantly accelerate the wound healing process under the synergistic effect of electrical stimulation(ES).PADM-MX-Ag-Si@Dox has demonstrated remarkable antimicrobial and electrophysiological activities,thereby establishing a robust basis for enhancing wound healing and facilitating real-time postoperative tumor surveillance.Extensive in vitro and in vivo investigations have substantiated that the combined utilization of PADM-MX-Ag-Si@Dox and ES results in a proactive amalgamation of melanoma postoperative relapse prevention,wound healing,and real-time postoperative surveillance,thereby establishing a potent therapeutic approach for postoperative cancer adjuvant therapy and paving the way for novel precision medical care.
出处 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2024年第21期155-168,共14页 材料科学技术(英文版)
基金 financial support from the National Natural Science Foundation of China(Nos.22278257 and 21804084) the Key Research and the Development Program of Shaanxi Province(No.2022GY-272) the Scientific Research Plan Projects of the Shaanxi Education Department(No.22JY013) the Young Talent Support Program Project of Shaanxi University of Science and Technology Association(No.20200424).
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