生长激素治疗生长激素缺乏症的时机探讨及疗效观察

Evaluation of the treatment and its timing with recombinant growth hormone on patients with idiopathic growth hormone deficiency treated

目的 :观察重组人生长激素 (r hGH)治疗原发性生长激素缺乏 (GHD)患儿的临床疗效 ,并探讨治疗的最佳时机。方法 :用r hGH治疗 18例GHD患者 1年 ,对比治疗前后生长指标的变化及不同骨龄阶段的生长效果。结果 :治疗后患者身高标准差积分、生长速度 (GV)、身高年龄 (HA)及骨龄 (BA)较治疗前明显增加 (P <0 0 1) ,其中以治疗开始后的前 6月身高增长最快 ,相应骨龄的增长也最快。小骨龄组的患者GV、△HA及△BA明显快于大骨龄组。结论 :GH能有效的促进GHD患儿身高增长 ,GHD患儿宜尽早给予GH治疗。

Objective: To evaluate the effect and the timing of treament on patients with idiopathic growth hormone deficiency (GHD) treated with recombinant human growth hormone (r hGH) Method: The growth velocity (GV) and the maturation of bone age (BA) GV were evaluated by the TW2RUS method standardized for Chinese children in 18 GHD patients treated with r hGH for a course of one year Results: After the first 6 months and one year therapy, the GV, height age (HA) and BA were more significantly increased than before, especially in the first 6 months The GV, △HA and △BA in young BA group were increased faster than the old BA group Conclusion: GH replacement therapy promoted the length growth of bone Patient with GHD are suggested to be treated with r hGH as early as possible