1,6二磷酸果糖治疗重型颅脑损伤被引量：1

1,6-Fructose-diphosphate supplement in treating patients with acute severe brain injuries

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摘要目的　探讨 1,6二磷酸果糖 (FDP)治疗重型颅脑损伤的效果和安全性。方法　选择伤后 8h内入院的重型颅脑损伤病人 6 0例 ,以基本同等伤情随机分为两组 ,每组 30例。FDP组除接受常规治疗外 ,还接受FDP治疗 ,10g/d ,静脉滴注 ,疗程 10d。对照组常规治疗 ,不用FDP。比较两组死亡率、GCS、GOS等神经功能指标 ,并测定治疗前后血气、血液流变学指标及神经生化因子水平。结果　FDP组死亡率 (16 % )明显低于对照组 (2 9% ) ,FDP组血气分析结果明显改善 ,血液流变学指标明显降低 ,从而改善了微循环 ,降低了血液粘度 (P <0 .0 1)。生化水平分析显示FDP能明显升高脑内保护性生长因子SOD水平 ,有助于神经元保护。结论　对重型颅脑损伤患者 ,早期应用FDP对脑组织具有保护作用 ,能有效地降低重型颅脑损伤患者的死亡率。 Objective To evaluate the effect and safety of 1,6 fructose diphosphate (1,6 FDP) in acute severe brain injuries.Methods 60 patients of acute severe brain injuries within 8 hours from anset were included.They were randomly divided into two groups.The experiment group received 1,6 FDP 10g/day intravenous injection for 10 days.The control group received routine therapy without 1,6 FDP supplement.Mortality rate,GOS blood gas,blood rheological index and neuron growth factor were compared between these two groups.Results The mortality rate of the experiment group decreased compared with the control group.No adverse effect was found.Conclusions 1,6 FDP is effective and safe in treating acute severe brain injuries.

作者苏亦兵富壮

机构地区首都医科大学附属北京天坛医院神经外科

出处《北京医学》 CAS 北大核心 2002年第6期372-374,共3页 Beijing Medical Journal

关键词治疗脑外伤 1 6二磷酸果糖 FDP Brain injure 1,6 Fructose diphosphate

分类号 R651.15 [医药卫生—外科学]

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