C-反应蛋白对急性冠脉综合征的预后价值

Prognostic value of C-reactive protein in patients with acute coronary syndrome

目的 观察C 反应蛋白 (CRP)在冠心病急性冠脉综合征 (ACS)包括急性心肌梗塞 (AMI)和不稳定型心绞痛 (UA)中的变化 ,以了解ACS与炎症之间的关系。方法 测定ACS组 4 7例急性心肌梗塞、4 2例不稳定型心绞痛血清CRP含量 ,并与 4 5例稳定型心绞痛 (SA)对照。结果 ACS中CRP均增高 ,且大面积急性心肌梗塞升高最为明显 ,AMI与UA、AMI与SA、UA与SA之间比较 ,结果均有显著差异 (P <0 0 1)。在患者近期心脏主要事件比较急性心肌梗塞组中大面积心梗与小面积心梗 ,与UA、与SA比较 ,结果均有显著差异 (P <0 0 1)。结论 血清CRP水平是预测ACS心肌组织损伤程度和范围以及近期预后的有效指标。

Objective To study the levels of C reactive protein(CRP) in patients with acute coronary syndrome(ACS) including acute myocardial infarction(AMI) and unstable angina pecoris(UA) and seek to test whether ACS is associated with inflammation.Methods Ultrasensitive immunoassay was used to measure CRP levels in 47 patients with AMI and 42 patients with UA comparing to 45 patients with stable angina pectoris(SA).Results CRP levels were higher in ACS including to AMI(52.5±11.7mg/L(especially very higher in widely AMI) and UA(20.9±9.6mg/L)compared with SA(5.7±2.1mg/L)respectively( P <0 01).Recently acute coronary events are higher in AMI and UA than SA respectively( P <0 01).Conclusion These results suggest that CRP is an useful marker in prognosis of myocardial injuries of ACS.