细胞凋亡调节基因蛋白表达与前列腺癌的预后

Expression of apoptosis-regulating genes in prostatic carcinoma and their association with tumor prognosis

目的 :探讨细胞凋亡调节基因蛋白表达与前列腺癌临床预后的关系。方法 :采用免疫组化染色方法 ,检测 5 7例前列腺癌中Fas及其配体 (FasL)、bcl 2、bax的表达 ,并同前列腺癌临床和病理特征一起 ,先后进行单因素和多因素分析。结果 :bax在前列腺癌低分化肿瘤中的表达强于在高分化肿瘤中的表达 (P <0 0 5 ) ;FasL表达可能对生存预后有一定影响 ,而肿瘤分化程度与临床分期仍是重要的预后指标。结论 :FasL表达可能与前列腺癌预后有关。

Objective:To detemine the relationship between expression of apoptosis-regulating genes and prognosis in prostatic carcinoma(Pca). Methods:The expression of Fas, FasL, bcl-2 and bax in 57 cases of prostatic carcinoma tissues was detected by immunohistochemical staining method. Association with pathological grade, clinical stage and patient survival were studied. Univariate and multivariate analyses were done to determine the independent contributions of these proteins in predicting survival. Results: ①The expression of bax and bcl-2 was both relevant to the grade of Pca, the expression of bax was significantly higher in high-grade tumors than in low-grade tumors(P<0.05); ②The expression of FasL may play a role in Pca progression, while grade and stage of the tumor were still important prognostic factors.Conclusion:FasL might be related to the prognosis of Pca.