早期梅毒98例临床分析

Clinical analysis of 98 cases of early syphilis

目的 :分析近年梅毒发病的临床特征及不同药物对愈后的影响。方法 :对近 5年门诊资料完整的 98例早期梅毒病例进行临床及实验室追踪随访调查。结果 :①一期梅毒 2 1例 ,二期梅毒 72例 ,早期潜伏梅毒 5例。血清RPR及FTA ABS全部阳性。治疗 1年血清转阴率 :RPR及FTA ABS分别为 10 0 %,2 0 4 1%;②临床特点 :1例 73岁男性高龄发病 ,2例多种皮损共存 ,3例阴囊湿疹样皮损 ,门诊误诊率 7 14%;③ 3组药物 (A 苄星青霉素 ;B 头孢三嗪 ;C 红霉素 )治疗 :AB组P >0 0 5 ;BC组P <0 0 5 ;CA组P <0 0 5 ;结论 :近年早期梅毒发病年龄增大 ,皮损的多样性使误诊率增高 ;目前苄星青霉素仍不失为治疗早期梅毒的首选药 ,头孢三嗪亦有较好疗效 ;RPR检测仍是临床判愈的重要指标。

Objective:Recent year's clinical analysis of syphilis and medical effects for recovery. Methods:Carried out clinical and laboratory investigation for 98 cases from completed clinical information in the last 5 years. Results: ①In 21 cases for primary syphilis, 72 cases of secondary syphilis and 5 cases latent syphilis the serum PRR and FTA-ABS were all positive. After one year treatment, the ratio changed from positive to negative: RPR and FTA-ABS were 100% and 20.41% respetively. ②The clinical characteristic: One case was an aged male of 73 years old; two cases were various and simultaneous lesions and three cases were eczmatoid lesions on the scrotum. The miss diagnose rate was 7.14%. ③The treatments of 3 groups:A.Benzathini Benzylpenicillinum B.Ceftraxone Sodium. C.Erythromy cinum, A:B(P>0.05);B:C (P<0.05);C:A(P<0.05).Conclusion: The age catching for syphilis disease has been increased in recent years and also increased in missing diagnose rate for complex and various skin damage. At present, Benzathini Benzylpenicillinum is still the first choice medicine for the treatment of syphilis and RPR test is an important parameter for clinical evaluation of treatment. Ceftraxone Sodium is also a good choice for the treatment.